Department of Obstetrics and Gynecology, Faculty of Medicine, Toho University, Ota-ku, Japan.
Reproduction Center, Toho University Omori Medical Center, Ota-ku, Japan.
Gynecol Endocrinol. 2020 Dec;36(12):1144-1148. doi: 10.1080/09513590.2020.1822805. Epub 2020 Sep 18.
Turner syndrome (TS) is associated with hypergonadotropic hypogonadism due to gonadal dysgenesis, which results in premature ovarian failure and subsequent infertility. Therefore, counseling and evaluation for fertility preservation are required as early as possible for women with TS.
A 23-year-old unmarried woman with mosaic TS (45, X [4/30] 46, XX [26/30]) presented to the pediatric department of our hospital for fertility counseling; she was accompanied by her mother. She was referred to the reproduction center of our hospital for ovarian reserve assessment and counseling regarding fertility preservation. We decided to retrieve oocytes using DuoStim as the controlled ovarian stimulation protocol. During the first and second oocyte retrievals, a total of 17 (9 and 8, respectively) mature metaphase II oocytes were cryopreserved.
DuoStim may be a useful option for fertility preservation for women with TS and reduced ovarian reserve. This new strategy may obtain the required number of oocytes in the shortest time and preserve the future fertility of women with TS.
特纳综合征（TS）由于性腺发育不全导致促性腺激素性性腺功能减退，从而导致卵巢早衰和随后的不孕。因此，对于患有 TS 的女性，尽早进行生育力保存的咨询和评估是必要的。
一位 23 岁未婚女性，患有镶嵌型 TS（45，X [4/30] 46，XX [26/30]），因生育咨询问题到我院儿科就诊；她由其母亲陪同。她被转至我院生殖中心进行卵巢储备评估和生育力保存咨询。我们决定使用 DuoStim 作为控制性卵巢刺激方案来取卵。在第一次和第二次取卵中，分别冷冻了 17 枚（9 枚和 8 枚）成熟的 MII 卵母细胞。
DuoStim 可能是卵巢储备减少的 TS 女性生育力保存的一种有效选择。这种新策略可能在最短的时间内获得所需数量的卵母细胞，并保留 TS 女性的未来生育能力。
