对11号染色体上六个基因座的多点图谱研究。

Multipoint mapping studies of six loci on chromosome 11.

作者信息

Meyers D A, Beaty T H, Maestri N E, Kittur S D, Antonarakis S E, Kazazian H H

出版信息

Hum Hered. 1987;37(2):94-101. doi: 10.1159/000153683.

Abstract

The six loci, beta-globin (HBBC), parathyroid hormone (PTH), oncogene c-Ha-ras-1 (HRAS1), insulin (INS), calcitonin (CAL) and catalase (CAT) loci, have been mapped to 11p in the order: CAT-CAL-PTH-HBBC-(HRAS1-INS). The purpose of the current study was to examine the linkage relationships, especially the multipoint relationships of these loci in detail. In the 18 families studied, a significant sex difference in recombination was found for the HBBC: HRAS1 linkage with more recombination in the male parent than the female parent (22 vs. 2%). The results of the multipoint analyses provided further evidence for the order CAT-CAL-PTH-HBBC-(HRAS1-INS); however, the order of the last two tightly linked loci is still not clear.

摘要

六个基因座，即β-珠蛋白（HBBC）、甲状旁腺激素（PTH）、癌基因c-Ha-ras-1（HRAS1）、胰岛素（INS）、降钙素（CAL）和过氧化氢酶（CAT）基因座，已按以下顺序定位到11号染色体短臂：CAT-CAL-PTH-HBBC-（HRAS1-INS）。本研究的目的是详细研究这些基因座的连锁关系，尤其是多点关系。在研究的18个家系中，发现HBBC与HRAS1连锁存在显著的性别重组差异，父本的重组率高于母本（分别为22%和2%）。多点分析结果进一步证明了CAT-CAL-PTH-HBBC-（HRAS1-INS）的顺序；然而，最后两个紧密连锁基因座的顺序仍不明确。