Department of Ophthalmology, Azienda USL - IRCCS, Reggio Emilia, Italy.
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Ocul Immunol Inflamm. 2022 Feb 17;30(2):290-293. doi: 10.1080/09273948.2020.1811351. Epub 2020 Sep 18.
Epstein-Barr Virus (EBV) has been previously reported to cause rare occurrence of mostly epithelial and nummular keratitis. We hereby report two patients developing bilateral peripheral deep interstitial keratitis following EBV-related infectious mononucleosis (IM).
Two female adolescents presented with findings of chronic relapsing posterior interstitial keratitis with neovascularisation mostly located in the superior and inferior peripheral cornea, in absence of signs of anterior uveitis. The disease presented months after the occurrence of IM. Other etiologies of interstitial keratitis were excluded. EBV DNA could not be detected in the aqueous humor of both patients. The patients responded promptly to topical corticosteroids, with multiple recurrences reported in one case.
EBV-induced IM can cause bilateral peripheral interstitial keratitis with delayed onset. Progressive relapsing course of the keratitis can be observed.
已报道 EBV（Epstein-Barr Virus）可引起罕见的上皮性和钱币状角膜炎。我们在此报告两例 EBV 相关传染性单核细胞增多症（IM）后发生双侧周边深层间质性角膜炎的患者。
两名女性青少年表现为慢性复发性后发性间质性角膜炎，伴有血管化，主要位于上、下周边角膜，无前葡萄膜炎的迹象。疾病在 IM 发生数月后出现。排除了其他间质性角膜炎的病因。两名患者的房水中均未检测到 EBV DNA。患者对局部皮质类固醇反应迅速，一例出现多次复发。
EBV 诱导的 IM 可引起双侧周边性间质性角膜炎，发病时间延迟。可观察到角膜炎进行性复发的病程。
