School of Mathematics and Computer Science, Gannan Normal University, Ganzhou, Jiangxi, China.
PLoS One. 2020 Sep 18;15(9):e0239144. doi: 10.1371/journal.pone.0239144. eCollection 2020.
In genome-wide association studies (GWAS), a wide variety of analysis tools have been designed, leading to various formats of GWAS data. How to convert a dataset in non-PLINK format into PLINK format to use its powerful analysis performance, or to convert a dataset in PLINK format into the format of other analysis tools, is a problem that needs to be faced and solved. To address this issue, we developed a tool called coPLINK, a complementary tool to PLINK, to cooperate with PLINK to implement the conversions of GWAS data formats and to provide some additional functions, such as data files comparison. The tool can implement mutual conversions not only between an existing data format and PLINK PED/BED, but also between a user-defined data format and PLINK PED. The usage and performance of the tool are similar to PLINK. The characteristics of the conversions of existing data formats and user-defined formats make it be a good assistant to PLINK or other tools and, have good potential for GWAS studies or other works.
在全基因组关联研究（GWAS）中，设计了各种各样的分析工具，导致出现了各种格式的 GWAS 数据。如何将非 PLINK 格式的数据集转换为 PLINK 格式以利用其强大的分析性能，或者将 PLINK 格式的数据集转换为其他分析工具的格式，是一个需要面对和解决的问题。为了解决这个问题，我们开发了一个名为 coPLINK 的工具，它是 PLINK 的补充工具，用于实现 GWAS 数据格式的转换，并提供一些附加功能，如数据文件比较。该工具不仅可以在现有数据格式和 PLINK PED/BED 之间，还可以在用户定义的数据格式和 PLINK PED 之间进行互转换。该工具的用法和性能与 PLINK 相似。现有数据格式和用户定义格式的转换特点使其成为 PLINK 或其他工具的良好助手，并且在 GWAS 研究或其他工作中具有很好的潜力。
