Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA.
Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA.
Hum Pathol. 2020 Nov;105:47-52. doi: 10.1016/j.humpath.2020.09.001. Epub 2020 Sep 16.
Special AT-rich sequence-binding protein 2 (SATB2) is a sensitive and specific marker for tumors originating with the colon and appendix. It is now commonly used in surgical pathology, while working up carcinomas of unknown primary. We had anecdotally encountered occasional hepatocellular carcinomas (HCCs) that were SATB2 positive. Immunohistochemical expression of SATB2 in HCC has not yet been examined in detail. In this study, we evaluated SATB2 expression in 46 HCCs. Nineteen (41%) of 46 HCCs were positive for SATB2. SATB2 expression in HCCs was more commonly seen in poorly differentiated tumors (11 of 13 cases, 85%) than well and moderately differentiated tumors (8 of 33 cases, 24%), p value = 0.0001. No other statistically significant correlations were observed (p > 0.05). There were no other statistically significant correlations between SATB2 expression and age, gender, background liver disease, and cirrhosis (p > 0.05). Results of our study show that a significant subset (41%) of HCCs can be SATB2 positive. Awareness of this phenomenon is important as SATB2 expression in a liver tumor does not completely exclude a diagnosis of HCC.
富含特殊 AT 序列结合蛋白 2（SATB2）是一种对来源于结肠和阑尾的肿瘤敏感且特异的标志物。它现在常用于外科病理学，在诊断不明原发灶的癌时。我们偶然遇到过偶尔呈 SATB2 阳性的肝细胞癌（HCC）。SATB2 在 HCC 中的免疫组化表达尚未详细研究。在这项研究中，我们评估了 46 例 HCC 中 SATB2 的表达。46 例 HCC 中有 19 例（41%）SATB2 阳性。SATB2 在 HCC 中的表达在低分化肿瘤（13 例中的 11 例，85%）中比高分化和中分化肿瘤（33 例中的 8 例，24%）更常见，p 值=0.0001。未观察到其他具有统计学意义的相关性（p＞0.05）。SATB2 表达与年龄、性别、背景肝病和肝硬化之间也没有其他具有统计学意义的相关性（p＞0.05）。我们的研究结果表明，相当一部分（41%）HCC 可以呈 SATB2 阳性。了解这一现象很重要，因为肝脏肿瘤中 SATB2 的表达并不能完全排除 HCC 的诊断。
