Lowe N J, Urbach F, Bailin P, Weingarten D P
J Am Acad Dermatol. 1987 May;16(5 Pt 1):994-8. doi: 10.1016/s0190-9622(87)70128-5.
Two alternate oral formulations of 8-methoxypsoralen, one liquid and the other crystalline, were evaluated in a double-blind trial for their comparative efficacy in combination with ultraviolet A (UVA) light in the treatment of severe psoriasis. With the liquid formulation a greater proportion of patients achieved a good clinical result within the 20 treatment sessions than patients receiving the crystalline formulation. This difference is even more striking using a more rigorous criterion of clearance. Among all patients who achieved clearance, no significant differences were seen in either the number of treatments required or in the total UVA energy employed between the two groups. The preceding clinical results are discussed in light of published pharmacokinetic data.
对8-甲氧基补骨脂素的两种口服剂型（一种为液体制剂，另一种为结晶制剂）进行了双盲试验，评估它们与紫外线A（UVA）光联合治疗重度银屑病的相对疗效。使用液体制剂时，在20次治疗疗程内达到良好临床效果的患者比例高于接受结晶制剂的患者。采用更严格的清除标准时，这种差异更为显著。在所有实现清除的患者中，两组之间在所需治疗次数或所用UVA总能量方面均未观察到显著差异。根据已发表的药代动力学数据对上述临床结果进行了讨论。
