牙髓再生：为老龄化人口提供的当前方法、挑战和新颖的 rejuvenating 策略。

Pulp Regeneration: Current Approaches, Challenges, and Novel Rejuvenating Strategies for an Aging Population.

机构信息

Department of Stem Cell Biology and Regenerative Medicine, National Center for Geriatrics and Gerontology, Research Institute, Obu, Aichi, Japan; Department of Oral Disease Research, National Center for Geriatrics and Gerontology, Research Institute, Obu, Aichi, Japan; Air Water Group, Aeras Bio Inc, Kobe, Hyogo, Japan.

Department of Stem Cell Biology and Regenerative Medicine, National Center for Geriatrics and Gerontology, Research Institute, Obu, Aichi, Japan.

出版信息

J Endod. 2020 Sep;46(9S):S135-S142. doi: 10.1016/j.joen.2020.06.028.

DOI:10.1016/j.joen.2020.06.028

PMID:32950185

Abstract

We showed the safety and efficacy of pulp regenerative therapy by the autologous transplantation of mobilized dental pulp stem cells with granulocyte colony-stimulating factor in a pilot clinical study of young and middle-aged pulpectomized teeth. An experimental study in dogs further demonstrated an age-dependent decline in the amount of regenerated pulp tissue. In our society, in which people will soon live beyond 100 years, this therapy should be efficacious for contributing to the functional survival and endurance of the tooth not only for pulpectomized young teeth but also for aged teeth with periapical disease. However, there are 2 challenges: 1 is enhancing pulp regeneration in aged teeth, and another is complete disinfection before cell transplantation. Thus, this review presents trypsin pretreatment for the former and a novel irrigant, nanobubbles with antibacterial nanopolymers, for the latter, thus demonstrating potential utility for pulp regenerative therapy in aged teeth with periapical disease.

摘要

我们通过自体动员牙髓干细胞与粒细胞集落刺激因子移植在年轻和中年牙髓切断牙的初步临床研究中显示了牙髓再生治疗的安全性和有效性。在狗的实验研究中进一步表明，再生牙髓组织的量随年龄的增长而减少。在我们的社会中，人们很快将活到 100 岁以上，这种治疗方法应该有效，不仅对牙髓切断的年轻牙齿，而且对根尖周病的老年牙齿，有助于牙齿的功能存活和耐久性。然而，存在 2 个挑战：1 是增强老年牙齿的牙髓再生，另一个是细胞移植前的完全消毒。因此，本综述提出了用胰蛋白酶预处理前者，以及用具有抗菌纳米聚合物的纳米气泡作为新型冲洗剂，从而为根尖周病老年牙齿的牙髓再生治疗提供了潜在的应用。