Gluud C, Henriksen J H
J Hepatol. 1987 Apr;4(2):168-73. doi: 10.1016/s0168-8278(87)80076-4.
Liver haemodynamics and liver function were measured in 34 alcoholic cirrhotic men before entry and after 12 months (median) in a double-blind, placebo-controlled study on the effect of oral testosterone treatment (200 mg t.i.d.). Comparing data at entry with those at follow-up in the total patient group, a significant change in median values of portal pressure (-23%, n = 34, P less than 0.005), hepatic blood flow (-22%, n = 28, P less than 0.001), indocyanine green clearance (+16%, n = 29, P less than 0.01), and galactose elimination capacity (+8%, n = 31, P less than 0.05) was observed. However, testosterone-treated patients did not differ significantly from placebo-treated patients regarding any of the measured variables. No significant relationships could be demonstrated between ethanol consumption and liver haemodynamics and liver function, but the number of patients consuming more than 100 g ethanol per day decreased significantly (P less than 0.001) from 22 (65%) before entry to one (3%) during follow-up. In conclusion, oral testosterone treatment of men with alcoholic cirrhosis does not explain the significant improvement of liver haemodynamics and function observed in this study. However, the improvement may be due to reduced ethanol consumption.
在一项关于口服睾酮治疗（200毫克，每日三次）效果的双盲、安慰剂对照研究中，对34名酒精性肝硬化男性患者在入组前及12个月（中位数）后进行了肝脏血流动力学和肝功能测量。将整个患者组的入组数据与随访数据进行比较，观察到门静脉压力中位数（-23%，n = 34，P < 0.005）、肝血流量（-22%，n = 28，P < 0.001）、吲哚菁绿清除率（+16%，n = 29，P < 0.01）和半乳糖清除能力（+8%，n = 31，P < 0.05）有显著变化。然而，在任何测量变量方面，睾酮治疗组患者与安慰剂治疗组患者之间没有显著差异。乙醇摄入量与肝脏血流动力学和肝功能之间未显示出显著关系，但每天摄入超过100克乙醇的患者数量从入组前的22名（65%）显著减少（P < 0.001）至随访期间的1名（3%）。总之，对酒精性肝硬化男性患者进行口服睾酮治疗并不能解释本研究中观察到的肝脏血流动力学和功能的显著改善。然而，这种改善可能是由于乙醇摄入量减少所致。
