Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Department of Pathophysiology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Int J Biochem Cell Biol. 2020 Nov;128:105850. doi: 10.1016/j.biocel.2020.105850. Epub 2020 Sep 17.
Venous thrombosis is a life-threatening condition with high morbidity and mortality. Abnormal functioning of different cells in the blood is an integral part of its pathogenesis. In this review, we describe the contribution of bone marrow-derived cells to the development of this debilitating disease. We present both epidemiological and clinical data demonstrating involvement of various cell types in venous thrombosis, and discuss potential mechanisms underlying these effects. Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized.
静脉血栓形成是一种危及生命的疾病，具有高发病率和死亡率。血液中不同细胞的异常功能是其发病机制的一个组成部分。在这篇综述中，我们描述了骨髓来源的细胞对这种使人衰弱的疾病发展的贡献。我们呈现了流行病学和临床数据，证明了各种细胞类型在静脉血栓形成中的参与，并讨论了这些影响的潜在机制。总结了现代概念，包括最近发现的血栓形成中的新范例，如中性粒细胞细胞外陷阱、肥大细胞和多磷酸盐。
