Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Complement Ther Med. 2020 Aug;52:102451. doi: 10.1016/j.ctim.2020.102451. Epub 2020 May 23.
Several trials have examined the effect of Garcinia cambogia supplement on the weight and body composition, but their results are conflicting. This systematic review and dose-response meta-analysis was designed to determine the effect of Garcinia cambogia supplement on the obesity indices in human randomized controlled trials (RCTs).
PubMed/Medline, Scopus, Cochrane library, and Web of Science databases were searched up to 1 January, 2020, to screen relevant trials. The mean changes in the weight, body mass index (BMI), percentage of fat mass (PFM), and waist circumference (WC) from the baseline were used to conduct the present dose response meta-analysis.
In the current study, eight trials (including 530 subjects) were included. Garcinia cambogia supplement significantly reduced the weight by -1.34 kg (95% CI: -2.62 to -0.07, P = 0.03), BMI by -0.99 kg/m (95% CI: -1.48 to -0.49, P < 0.001), PFM by -0.42% (95% CI: -0.77 to -0.06, P = 0.02), and WC by -4.16 cm (95% CI: -7.83 to -0.49, P = 0.02) compared with the placebo group. Dose-response analysis revealed that there is a nonlinear association between Garcinia cambogia dosage and changes in the body weight (P = 0.04) and BMI (P < 0.001) not PFM (P = 0.68). There was no publication bias among the studies.
Our results suggested that Garcinia cambogia supplement had a significant effect on the body weight, BMI, PFA, and WC as compared with the placebo.
多项试验已经研究了藤黄果补充剂对体重和身体成分的影响，但结果相互矛盾。本系统评价和剂量反应荟萃分析旨在确定藤黄果补充剂对人体随机对照试验（RCT）中肥胖指数的影响。
截至 2020 年 1 月 1 日，检索了 PubMed/Medline、Scopus、Cochrane 图书馆和 Web of Science 数据库，以筛选相关试验。使用基线时体重、体重指数（BMI）、体脂肪百分比（PFM）和腰围（WC）的平均变化进行本次剂量反应荟萃分析。
在本研究中，纳入了八项试验（包括 530 名受试者）。藤黄果补充剂可显著降低体重 -1.34kg（95%CI：-2.62 至 -0.07，P=0.03）、BMI -0.99kg/m（95%CI：-1.48 至 -0.49，P<0.001）、PFM -0.42%（95%CI：-0.77 至 -0.06，P=0.02）和 WC -4.16cm（95%CI：-7.83 至 -0.49，P=0.02）与安慰剂组相比。剂量反应分析表明，藤黄果剂量与体重变化（P=0.04）和 BMI（P<0.001）而非 PFM（P=0.68）之间存在非线性关系。研究之间没有发表偏倚。
与安慰剂相比，我们的结果表明藤黄果补充剂对体重、BMI、PFA 和 WC 有显著影响。
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