碱基编辑全景延伸至颠换突变。
Base Editing Landscape Extends to Perform Transversion Mutation.
机构信息
Indian Council of Agricultural Research (ICAR)-National Rice Research Institute (NRRI), Cuttack-753006, India.
Department of Plant Science and Landscape Architecture, University of Maryland, College Park, MD 20742, USA; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
出版信息
Trends Genet. 2020 Dec;36(12):899-901. doi: 10.1016/j.tig.2020.09.001. Epub 2020 Sep 18.
Base editors have drawn considerable academic and industrial attention in recent years because of their ability to alter single DNA bases with precision. However, the existing cytosine and adenine base editors can only install transition mutations. Three recent studies (Kurt et al.,Zhao et al., and Chen et al.) expand the base editing toolbox by developing cytosine transversion base editors.
碱基编辑器近年来因其精确改变单个 DNA 碱基的能力而引起了广泛的学术和工业关注。然而，现有的胞嘧啶和腺嘌呤碱基编辑器只能引入转换突变。最近的三项研究（Kurt 等人、Zhao 等人和 Chen 等人）通过开发胞嘧啶颠换碱基编辑器扩展了碱基编辑工具包。
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