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关节软骨中声速与压缩之间的非线性关系:测量与建模

The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling.

作者信息

Mansour Joseph M, Motavalli Mostafa, Bensusan Jay, Li Ming, Margevicius Seunghee, Welter Jean F

机构信息

Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH, USA.

Case Center for Multimodal Evaluation of Engineered Cartilage, Case Western Reserve University, Cleveland, OH, USA.

出版信息

J Mech Behav Biomed Mater. 2020 Oct;110. doi: 10.1016/j.jmbbm.2020.103923. Epub 2020 Jun 19.

DOI:10.1016/j.jmbbm.2020.103923
PMID:32952604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7493830/
Abstract

We measured speed of sound in bovine articular cartilage as a function of compressive strain. Using techniques we developed, it was possible to apply strain starting from the unstrained, full height of a sample. Our measurements showed that speed of sound was not a monotonic function of strain as reported in earlier investigations. Speed increased with increasing strain over a range of lower strains. It reached a maximum, and then decreased as the strain increased further. These results were corroborated using a model of wave propagation in deformable porous materials. Using this model, we also established conditions under which a maximum in the speed would exist for samples in compression. Our measurements and analysis resolve the conflicting results reported in previous studies.

摘要

我们测量了牛关节软骨中声速随压缩应变的变化情况。利用我们开发的技术,可以从样品未受应变的全高开始施加应变。我们的测量结果表明,声速并非如早期研究所报道的那样是应变的单调函数。在较低应变范围内,声速随应变增加而增大。它达到最大值,然后随着应变进一步增加而减小。使用可变形多孔材料中的波传播模型证实了这些结果。利用该模型,我们还确定了压缩样品中声速存在最大值的条件。我们的测量和分析解决了先前研究中报道的相互矛盾的结果。

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1
The nonlinear relationship between speed of sound and compression in articular cartilage: Measurements and modeling.关节软骨中声速与压缩之间的非线性关系:测量与建模
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本文引用的文献

1
Depth-dependent shear behavior of bovine articular cartilage: relationship to structure.牛关节软骨的深度依赖性剪切行为:与结构的关系
J Anat. 2014 Nov;225(5):519-26. doi: 10.1111/joa.12230. Epub 2014 Aug 21.
2
Towards the feasibility of using ultrasound to determine mechanical properties of tissues in a bioreactor.关于使用超声测定生物反应器中组织力学性能的可行性研究。
Ann Biomed Eng. 2014 Oct;42(10):2190-202. doi: 10.1007/s10439-014-1079-4. Epub 2014 Aug 5.
3
How changes in fibril-level organization correlate with the macrolevel behavior of articular cartilage.纤维水平的组织变化如何与关节软骨的宏观行为相关联。
Wiley Interdiscip Rev Syst Biol Med. 2013 Jul-Aug;5(4):495-509. doi: 10.1002/wsbm.1220. Epub 2013 Apr 1.
4
Quantitative ultrasound biomicroscopy for the analysis of healthy and repair cartilage tissue.定量超声生物显微镜分析健康和修复软骨组织。
Eur Cell Mater. 2010 Feb 26;19:58-71. doi: 10.22203/ecm.v019a07.
5
Ultrasound elastography to determine the layered mechanical properties of articular cartilage and the importance of such structural characteristics under load.超声弹性成像用于确定关节软骨的分层力学特性以及此类结构特征在负荷下的重要性。
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4262-5. doi: 10.1109/IEMBS.2009.5334589.
6
High-resolution spatial mapping of shear properties in cartilage.软骨剪切特性的高分辨率空间测绘。
J Biomech. 2010 Mar 3;43(4):796-800. doi: 10.1016/j.jbiomech.2009.10.012. Epub 2009 Nov 5.
7
Differences in acoustic properties of intact and degenerated human patellar cartilage during compression.完整和退变的人髌软骨在压缩过程中的声学特性差异。
Ultrasound Med Biol. 2009 Aug;35(8):1367-75. doi: 10.1016/j.ultrasmedbio.2009.03.003. Epub 2009 Jun 21.
8
Strain-dependent modulation of ultrasound speed in articular cartilage under dynamic compression.动态压缩下关节软骨中超声速度的应变依赖性调制
Ultrasound Med Biol. 2009 Jul;35(7):1177-84. doi: 10.1016/j.ultrasmedbio.2009.03.002. Epub 2009 May 7.
9
Mapping the depth dependence of shear properties in articular cartilage.绘制关节软骨剪切特性的深度依赖性。
J Biomech. 2008 Aug 7;41(11):2430-7. doi: 10.1016/j.jbiomech.2008.05.021. Epub 2008 Jul 10.
10
Deep vertical collagen fibrils play a significant role in mechanics of articular cartilage.深层垂直胶原纤维在关节软骨力学中起重要作用。
J Orthop Res. 2008 May;26(5):608-15. doi: 10.1002/jor.20537.