Hogan Y, Lee C M
J Natl Med Assoc. 1987 May;79(5):521-31.
The influence of trace metal contaminants (lead, cadmium, and mercury) on Sprague-Dawley rats was investigated to determine whether subclinical levels of these metals might have adverse effects on the host's ability to respond to an infective agent.In the present study, a trace metal contaminant-trypanosome system was employed to observe the hematological changes in rats infected with Trypanosoma lewisi. The animal groups were: (1) lead (Pb), (2) cadmium (Cd), (3) mercury (Hg), and (4) controls (animals not exposed to trace metals).Regardless of the trace metals, infected animals showed decreases in total erythrocyte counts and lower hematocrit values. Generally, infected animals also showed increases in total leucocyte counts, decreases in the percentages of lymphocytes and monocytes, increases in percentage of neutrophils, and no changes in percentages of eosinophils and basophils.
研究了痕量金属污染物（铅、镉和汞）对斯普拉格-道利大鼠的影响，以确定这些金属的亚临床水平是否可能对宿主应对感染因子的能力产生不利影响。在本研究中，采用痕量金属污染物-锥虫系统来观察感染刘易斯锥虫的大鼠的血液学变化。动物组包括：（1）铅（Pb）组，（2）镉（Cd）组，（3）汞（Hg）组，以及（4）对照组（未接触痕量金属的动物）。无论接触何种痕量金属，受感染的动物红细胞总数均减少，血细胞比容值降低。一般来说，受感染的动物白细胞总数也增加，淋巴细胞和单核细胞百分比降低，中性粒细胞百分比增加，嗜酸性粒细胞和嗜碱性粒细胞百分比无变化。
