Hogan Y, Lee C M
J Natl Med Assoc. 1988 Nov;80(11):1217-27.
The effects of trace metal contaminants (lead, cadmium, and mercury) on the immunologic responses of rats infected with Trypanosoma lewisi were investigated to determine whether chronic exposures to subclinical levels of these metals have adverse effects on the host's ability to respond to an infective agent.Earlier and higher levels of parasitemia were detected in animals exposed to cadmium, lead, and mercury. The variability in length of trypanosome cells in metal-exposed animals became constant at a later time and persisted for a longer time, indicating a delay in antibody synthesis. Serum levels of IgG and IgM were increased in infected animals exposed to trace metals; however, lower levels were observed when compared with infected control animals. Animals exposed only to trace metals showed decreases in serum levels of IgG and IgM. In contact sensitivity to dinitrofluorobenzene (DNFB), animals exposed to trace metals demonstrated no significant difference in sensitization when compared with those infected and exposed to trace metals.
研究了痕量金属污染物（铅、镉和汞）对感染刘易斯锥虫的大鼠免疫反应的影响，以确定长期暴露于这些金属的亚临床水平是否会对宿主对感染因子的反应能力产生不利影响。在接触镉、铅和汞的动物中检测到更早且更高水平的寄生虫血症。接触金属的动物体内锥虫细胞长度的变异性在后期变得恒定，并持续更长时间，这表明抗体合成延迟。接触痕量金属的感染动物血清中IgG和IgM水平升高；然而，与感染的对照动物相比，观察到的水平较低。仅接触痕量金属的动物血清中IgG和IgM水平降低。在对二硝基氟苯（DNFB）的接触敏感性方面，与感染并接触痕量金属的动物相比，接触痕量金属的动物在致敏方面没有显著差异。
