Cardiology Units, Afe Babalola Multisystem Hospital, Ekiti State University Teaching Hospital, Ado-Ekiti, Ekiti State, Nigeria.
Cardiology Unit, Federal Teaching Hospital Ado-Ekiti, Ekiti State, Nigeria.
Pan Afr Med J. 2020 Jul 16;36:190. doi: 10.11604/pamj.2020.36.190.21072. eCollection 2020.
systemic hypertension is a foremost risk factor for cardiovascular morbidity and mortality. Its actions are manifested on organs like the brain, heart and kidneys. High serum uric acid (SUA) escalates cardiovascular vulnerability in patients with systemic hypertension.
a cross-sectional study was performed in 271 (178 females, 93 males) patients with systemic hypertension. Two hundred and seventy one healthy age and sex matched non-hypertensive persons obliged as controls. Left ventricular hypertrophy (LVH) was estimated by echocardiography. Blood samples were collected for measuring uric acid levels.
mean SUA was significantly higher among the hypertensive patients (371±125μmol/L) than in the controls (269 ± 101.4μmol/L; p < 0.001), and the prevalence of hyperuricemia was 46.9% among the hypertensives and 11.1% among the controls (P < 0.001). Independent predictors of SUA were class of systemic hypertension, left ventricular mass index (LVMI), body mass index (BMI) and age. However, class of hypertension was the best independent predictor of SUA levels in the multivariate regression model (β = 0.597). Linear regression revealed SUA levels ≥ 430μmols/l as a predictor of stage 2 hypertension (F = 26.620, p = < 0.001). Among the hypertensive patients, LVH was present in 39.3% of those with hyperuricemia and in 28.0% of those with normal SUA levels (p = 0.003).
results indicate serum uric acid is positively correlated with hypertension and a reliable indicator of LVH in study population.
系统性高血压是心血管发病率和死亡率的首要危险因素。其作用表现在大脑、心脏和肾脏等器官上。高血清尿酸（SUA）会增加系统性高血压患者的心血管脆弱性。
对 271 名（178 名女性，93 名男性）系统性高血压患者进行了横断面研究。271 名年龄和性别相匹配的非高血压健康人作为对照组。通过超声心动图估计左心室肥厚（LVH）。采集血样测量尿酸水平。
高血压患者的平均 SUA 明显高于对照组（371±125μmol/L 比 269±101.4μmol/L；p<0.001），高血压患者中高尿酸血症的患病率为 46.9%，对照组为 11.1%（P<0.001）。SUA 的独立预测因子为系统性高血压的类别、左心室质量指数（LVMI）、体重指数（BMI）和年龄。然而，在多元回归模型中，高血压类别是 SUA 水平的最佳独立预测因子（β=0.597）。线性回归显示，SUA 水平≥430μmols/l 是 2 期高血压的预测因子（F=26.620，p<0.001）。在高血压患者中，高尿酸血症组的 LVH 发生率为 39.3%，而 SUA 水平正常组的 LVH 发生率为 28.0%（p=0.003）。
结果表明，血清尿酸与高血压呈正相关，是研究人群中 LVH 的可靠指标。
