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Alternative splicing of HER2: a novel mediator of EGFR TKI resistance.

作者信息

Yochum Zachary A, Villaruz Liza C

机构信息

Division of Hematology-Oncology, Department of Medicine, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

出版信息

Transl Lung Cancer Res. 2020 Aug;9(4):1606-1612. doi: 10.21037/tlcr-20-618.

DOI:10.21037/tlcr-20-618
PMID:32953533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7481647/
Abstract
摘要

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本文引用的文献

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Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance Mutations.一线奥希替尼耐药突变的药物敏感性和等位基因特异性。
Cancer Res. 2020 May 15;80(10):2017-2030. doi: 10.1158/0008-5472.CAN-19-3819. Epub 2020 Mar 19.
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Cancer statistics, 2020.癌症统计数据,2020 年。
CA Cancer J Clin. 2020 Jan;70(1):7-30. doi: 10.3322/caac.21590. Epub 2020 Jan 8.
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Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in -Mutant Lung Cancer.
肿瘤分析揭示鳞状转化和脱靶改变是 - 突变肺癌一线奥希替尼耐药的早期机制。
Clin Cancer Res. 2020 Jun 1;26(11):2654-2663. doi: 10.1158/1078-0432.CCR-19-3563. Epub 2020 Jan 7.
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Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer.奥希替尼治疗 EGFR 突变型非小细胞肺癌的耐药机制。
Br J Cancer. 2019 Oct;121(9):725-737. doi: 10.1038/s41416-019-0573-8. Epub 2019 Sep 30.
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Exon 16-Skipping HER2 as a Novel Mechanism of Osimertinib Resistance in EGFR L858R/T790M-Positive Non-Small Cell Lung Cancer.外显子 16 跳跃 HER2 作为 EGFR L858R/T790M 阳性非小细胞肺癌中奥希替尼耐药的新机制
J Thorac Oncol. 2020 Jan;15(1):50-61. doi: 10.1016/j.jtho.2019.09.006. Epub 2019 Sep 23.
6
Triple Trouble: A Case of Multiple Resistance Mechanisms after First Generation EGFR-TKI in NSCLC.三重困境:1例非小细胞肺癌患者在第一代表皮生长因子受体酪氨酸激酶抑制剂治疗后出现多种耐药机制的病例
Case Rep Oncol. 2019 Aug 6;12(2):625-630. doi: 10.1159/000502214. eCollection 2019 May-Aug.
7
Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial.帕博利珠单抗对比化疗用于未经治疗、PD-L1 表达、局部晚期或转移性非小细胞肺癌(KEYNOTE-042):一项随机、开放标签、对照、III 期临床试验。
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Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer.靶向 EMT 转录因子 TWIST1 克服 EGFR 突变型非小细胞肺癌对 EGFR 抑制剂的耐药性。
Oncogene. 2019 Jan;38(5):656-670. doi: 10.1038/s41388-018-0482-y. Epub 2018 Aug 31.
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Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC.阿替利珠单抗作为转移性非鳞状 NSCLC 一线治疗药物。
N Engl J Med. 2018 Jun 14;378(24):2288-2301. doi: 10.1056/NEJMoa1716948. Epub 2018 Jun 4.