含硬脂胺脂质体的体外杀锥虫活性。
Trypanocidal activity of the stearylamine-bearing liposome in vitro.
作者信息
Yoshihara E, Tachibana H, Nakae T
出版信息
Life Sci. 1987 Jun 1;40(22):2153-9. doi: 10.1016/0024-3205(87)90005-1.
PMID:3295443
Abstract
Liposome made of stearylamine and phosphatidylcholine showed the trypanocidal activity in vitro. Cytotoxicity of the liposome against Trypanosoma cruzi appeared to be the strongest in trypomastigotes followed by amastigotes and epimastigotes. Lysis of the human erythrocyte was undetectably low under the conditions that the liposome kills more than 95% of trypomastigotes. The liposome seems to damage the plasma membrane.
摘要
由硬脂胺和磷脂酰胆碱制成的脂质体在体外显示出杀锥虫活性。脂质体对克氏锥虫的细胞毒性在锥鞭毛体中似乎最强，其次是无鞭毛体和上鞭毛体。在脂质体杀死超过95%的锥鞭毛体的条件下，人红细胞的裂解程度低到检测不到。该脂质体似乎会破坏质膜。
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