镓- DOTATATE PET-CT 检查在副神经节瘤中的假阳性。
False Positive of Ga-DOTATATE PET-CT in a Paraganglioma.
机构信息
ASST Grande Ospedale Metropolitano Niguarda, Endocrinology Department, Milan, Italy.
IRCCS Orthopedic Institute Galeazzi, Endocrinology Service, Milan, Italy.
出版信息
Endocr Metab Immune Disord Drug Targets. 2021;21(7):1352-1355. doi: 10.2174/1871530320666200821141256.
BACKGROUND
Functional imaging with Ga-DOTATATE PET-CT is widely employed to detect both primary and metastatic pheochromocytomas and paragangliomas (PGL), but its results may be occasionally misleading as in the case here reported.
CASE PRESENTATION
We report here a 75-year-old woman with an interaortocaval PGL that was diagnosed after a hypertensive crisis occurring during the resection of a kidney tumor. Ga-DOTATATE PET-CT disclosed pathologic uptake in the abdomen and at the iliac crest. After the resection of the abdominal tumor, with the histological confirmation of PGL, arterial blood pressure and metanephrine levels were normalized. Genetic testing was negative. Thereafter, the bone lesion increased in size and became painful, requiring multiple medications. A selective biopsy disclosed a metastatic lesion arising from the renal tumor.
CONCLUSION
The false-positive result of Ga-DOTATATE PET-CT is discussed.
背景
使用 Ga-DOTATATE PET-CT 进行功能成像被广泛用于检测原发性和转移性嗜铬细胞瘤和副神经节瘤（PGL），但正如这里报道的病例一样，其结果有时可能会产生误导。
病例介绍
我们在此报告一例 75 岁女性患者，其腹主动脉旁 PGL 在肾脏肿瘤切除过程中发生高血压危象后被诊断。Ga-DOTATATE PET-CT 显示腹部和髂嵴存在病理性摄取。腹部肿瘤切除后，PGL 的组织学证实，动脉血压和甲氧基肾上腺素水平恢复正常。基因检测为阴性。此后，骨病变增大并出现疼痛，需要多种药物治疗。选择性活检显示来自肾肿瘤的转移性病变。
结论
讨论了 Ga-DOTATATE PET-CT 的假阳性结果。
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