Department of Child Neurology, Medical University of Warsaw, Żwirki i Wigury 63A, 02-091 Warsaw, Poland.
Department of Radiology, Medical University of Warsaw,, Żwirki i Wigury 63A, 02-091 Warsaw, Poland.
Neurol Neurochir Pol. 2020;54(5):399-409. doi: 10.5603/PJNNS.a2020.0070. Epub 2020 Sep 21.
Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance imaging (MRI) to help with the diagnostic and monitoring processes of many diseases, including neurological disorders. Initially, it was assumed that GBCAs carry minimal risk, are safe and well tolerated. But recent reports of GBCA-associated deposition in many body tissues have raised concerns about the broader health impacts of gadolinium exposure. The aim of this review was to summarise knowledge regarding gadolinium deposition, primarily in the brain structures, and of potential GBCA-associated toxicity. Moreover, we discuss the current recommendations on the use of GBCAs, as well as alternative contrast agents and imaging techniques.
钆基造影剂（GBCAs）广泛应用于磁共振成像（MRI），有助于诊断和监测多种疾病，包括神经疾病。最初，人们认为 GBCAs 风险极小，安全且耐受良好。但最近有报道称 GBCA 与体内许多组织的沉积有关，这引起了人们对体内暴露于钆的更广泛健康影响的关注。本综述的目的是总结关于钆沉积的知识，主要是在脑结构中，以及潜在的 GBCA 相关毒性。此外，我们还讨论了目前关于 GBCAs 使用的建议，以及替代造影剂和成像技术。
