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2
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本文引用的文献

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COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study.欧洲儿童和青少年中的 COVID-19:一项多国家、多中心队列研究。
Lancet Child Adolesc Health. 2020 Sep;4(9):653-661. doi: 10.1016/S2352-4642(20)30177-2. Epub 2020 Jun 25.
2
Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2.58 例与 SARS-CoV-2 相关的儿童炎症性多系统综合征的临床特征。
JAMA. 2020 Jul 21;324(3):259-269. doi: 10.1001/jama.2020.10369.
3
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study.围手术期 SARS-CoV-2 感染患者的死亡率和肺部并发症:一项国际队列研究。
Lancet. 2020 Jul 4;396(10243):27-38. doi: 10.1016/S0140-6736(20)31182-X. Epub 2020 May 29.
4
Asymptomatic Transmission During the Coronavirus Disease 2019 Pandemic and Implications for Public Health Strategies.新型冠状病毒肺炎大流行期间的无症状传播及其对公共卫生策略的影响。
Clin Infect Dis. 2020 Dec 17;71(10):2752-2756. doi: 10.1093/cid/ciaa654.
5
Comparison of Cepheid Xpert Xpress and Abbott ID Now to Roche cobas for the Rapid Detection of SARS-CoV-2.Cepheid Xpert Xpress 和 Abbott ID Now 与 Roche cobas 用于 SARS-CoV-2 快速检测的比较。
J Clin Virol. 2020 Jul;128:104428. doi: 10.1016/j.jcv.2020.104428. Epub 2020 May 13.
6
Severe Coronavirus Disease-2019 in Children and Young Adults in the Washington, DC, Metropolitan Region.华盛顿特区都会区儿童和青年中的严重 2019 年冠状病毒病。
J Pediatr. 2020 Aug;223:199-203.e1. doi: 10.1016/j.jpeds.2020.05.007. Epub 2020 May 13.
7
SARS-CoV-2 testing and outcomes in the first 30 days after the first case of COVID-19 at an Australian children's hospital.澳大利亚一家儿童医院首例 COVID-19 病例出现后 30 天内的 SARS-CoV-2 检测和结果。
Emerg Med Australas. 2020 Oct;32(5):801-808. doi: 10.1111/1742-6723.13550. Epub 2020 Jun 23.
8
Hyperinflammatory shock in children during COVID-19 pandemic.新冠疫情期间儿童的高炎症性休克
Lancet. 2020 May 23;395(10237):1607-1608. doi: 10.1016/S0140-6736(20)31094-1. Epub 2020 May 7.
9
A Case of Critically Ill Infant of Coronavirus Disease 2019 With Persistent Reduction of T Lymphocytes.2019 年冠状病毒病危重症婴儿病例,表现为持续减少的 T 淋巴细胞。
Pediatr Infect Dis J. 2020 Jul;39(7):e87-e90. doi: 10.1097/INF.0000000000002720.
10
Temporal dynamics in viral shedding and transmissibility of COVID-19.新冠病毒脱落和传播的时间动态。
Nat Med. 2020 May;26(5):672-675. doi: 10.1038/s41591-020-0869-5. Epub 2020 Apr 15.

新冠疫情高峰期的儿科手术安全性:一项观察性研究。

The safety of paediatric surgery between COVID-19 surges: an observational study.

机构信息

Jackson Rees Department of Anaesthesia, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

出版信息

Anaesthesia. 2020 Dec;75(12):1605-1613. doi: 10.1111/anae.15264. Epub 2020 Oct 13.

DOI:10.1111/anae.15264
PMID:32955100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7537528/
Abstract

Despite the ongoing coronavirus disease 2019 (COVID-19) pandemic, elective paediatric surgery must continue safely through the first, second and subsequent waves of disease. This study presents outcome data from a children's hospital in north-west England, the region with the highest prevalence of COVID-19 in England. Children and young people undergoing elective surgery isolated within their household for 14 days, then presented for real-time reverse transcriptase polymerase chain reaction testing for severe acute respiratory syndrome coronavirus disease-2 (SARS-CoV-2) within 72 h of their procedure (or rapid testing within 24 h in high-risk cases), and completed a screening questionnaire on admission. Planned surgery resumed on 26 May 2020; in the four subsequent weeks, there were 197 patients for emergency and 501 for elective procedures. A total of 488 out of 501 (97.4%) elective admissions proceeded, representing a 2.6% COVID-19-related cancellation rate. There was no difference in the incidence of SARS-CoV-2 among children and young people who had or had not isolated for 14 days (p > 0.99). One out of 685 (0.1%) children who had surgery re-presented to the hospital with symptoms potentially consistent with SARS-CoV-2 within 14 days of surgery. Outcomes were similar to those in the same time period in 2019 for length of stay (p = 1.0); unplanned critical care admissions (p = 0.59); and 14-day hospital re-admission (p = 0.17). However, the current cohort were younger (p = 0.037); of increased complexity (p < 0.001) and underwent more complex surgery (p < 0.001). The combined use of household self-isolation, testing and screening questionnaires has allowed the re-initiation of elective paediatric surgery at high volume while maintaining pre-COVID-19 outcomes in children and young people undergoing surgery. This may provide a model for addressing the ongoing challenges posed by COVID-19, as well as future pandemics.

摘要

尽管目前仍处于 2019 年冠状病毒病(COVID-19)大流行之中,但小儿择期手术仍必须在疾病的第一波、第二波和后续波次中安全地进行。本研究介绍了英格兰西北部一家儿童医院的结果数据,该地区是英格兰 COVID-19 发病率最高的地区。接受择期手术的儿童和青少年在其家庭中隔离 14 天,然后在手术前 72 小时内(高危病例在 24 小时内进行快速检测)进行实时逆转录聚合酶链反应检测严重急性呼吸综合征冠状病毒疾病-2(SARS-CoV-2),并在入院时完成筛查问卷。计划于 2020 年 5 月 26 日恢复择期手术;在随后的四周内,有 197 名患者进行急诊手术,501 名患者进行择期手术。501 名择期入院患者中,共有 488 名(97.4%)继续进行手术,COVID-19 相关取消率为 2.6%。已隔离 14 天或未隔离 14 天的儿童和青少年中,SARS-CoV-2 的发病率无差异(p>0.99)。在手术后 14 天内,有 1 名接受手术的儿童再次因疑似 SARS-CoV-2 症状而回到医院就诊,占 685 名患者的 0.1%。在手术期间的同一时间段内,与 2019 年相比,住院时间(p=1.0)、非计划重症监护入院(p=0.59)和 14 天内再次住院(p=0.17)的结果相似。然而,当前的队列年龄更小(p=0.037)、病情更复杂(p<0.001),且接受了更复杂的手术(p<0.001)。家庭自我隔离、检测和筛查问卷的联合使用,使我们能够在维持 COVID-19 前手术结果的情况下,以高容量重新开始小儿择期手术。这可能为应对 COVID-19 以及未来的大流行带来的持续挑战提供一个模式。