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新冠疫情高峰期的儿科手术安全性:一项观察性研究。

The safety of paediatric surgery between COVID-19 surges: an observational study.

机构信息

Jackson Rees Department of Anaesthesia, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

出版信息

Anaesthesia. 2020 Dec;75(12):1605-1613. doi: 10.1111/anae.15264. Epub 2020 Oct 13.

Abstract

Despite the ongoing coronavirus disease 2019 (COVID-19) pandemic, elective paediatric surgery must continue safely through the first, second and subsequent waves of disease. This study presents outcome data from a children's hospital in north-west England, the region with the highest prevalence of COVID-19 in England. Children and young people undergoing elective surgery isolated within their household for 14 days, then presented for real-time reverse transcriptase polymerase chain reaction testing for severe acute respiratory syndrome coronavirus disease-2 (SARS-CoV-2) within 72 h of their procedure (or rapid testing within 24 h in high-risk cases), and completed a screening questionnaire on admission. Planned surgery resumed on 26 May 2020; in the four subsequent weeks, there were 197 patients for emergency and 501 for elective procedures. A total of 488 out of 501 (97.4%) elective admissions proceeded, representing a 2.6% COVID-19-related cancellation rate. There was no difference in the incidence of SARS-CoV-2 among children and young people who had or had not isolated for 14 days (p > 0.99). One out of 685 (0.1%) children who had surgery re-presented to the hospital with symptoms potentially consistent with SARS-CoV-2 within 14 days of surgery. Outcomes were similar to those in the same time period in 2019 for length of stay (p = 1.0); unplanned critical care admissions (p = 0.59); and 14-day hospital re-admission (p = 0.17). However, the current cohort were younger (p = 0.037); of increased complexity (p < 0.001) and underwent more complex surgery (p < 0.001). The combined use of household self-isolation, testing and screening questionnaires has allowed the re-initiation of elective paediatric surgery at high volume while maintaining pre-COVID-19 outcomes in children and young people undergoing surgery. This may provide a model for addressing the ongoing challenges posed by COVID-19, as well as future pandemics.

摘要

尽管目前仍处于 2019 年冠状病毒病(COVID-19)大流行之中,但小儿择期手术仍必须在疾病的第一波、第二波和后续波次中安全地进行。本研究介绍了英格兰西北部一家儿童医院的结果数据,该地区是英格兰 COVID-19 发病率最高的地区。接受择期手术的儿童和青少年在其家庭中隔离 14 天,然后在手术前 72 小时内(高危病例在 24 小时内进行快速检测)进行实时逆转录聚合酶链反应检测严重急性呼吸综合征冠状病毒疾病-2(SARS-CoV-2),并在入院时完成筛查问卷。计划于 2020 年 5 月 26 日恢复择期手术;在随后的四周内,有 197 名患者进行急诊手术,501 名患者进行择期手术。501 名择期入院患者中,共有 488 名(97.4%)继续进行手术,COVID-19 相关取消率为 2.6%。已隔离 14 天或未隔离 14 天的儿童和青少年中,SARS-CoV-2 的发病率无差异(p>0.99)。在手术后 14 天内,有 1 名接受手术的儿童再次因疑似 SARS-CoV-2 症状而回到医院就诊,占 685 名患者的 0.1%。在手术期间的同一时间段内,与 2019 年相比,住院时间(p=1.0)、非计划重症监护入院(p=0.59)和 14 天内再次住院(p=0.17)的结果相似。然而,当前的队列年龄更小(p=0.037)、病情更复杂(p<0.001),且接受了更复杂的手术(p<0.001)。家庭自我隔离、检测和筛查问卷的联合使用,使我们能够在维持 COVID-19 前手术结果的情况下,以高容量重新开始小儿择期手术。这可能为应对 COVID-19 以及未来的大流行带来的持续挑战提供一个模式。

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