Whitnall M H, Smyth D, Gainer H
Neuroendocrinology. 1987 May;45(5):420-4. doi: 10.1159/000124768.
Electron-microscopic immunocytochemistry of serial thin sections showed that, in normal rats, approximately 50% of corticotropin-releasing factor (CRF) axons in the external zone of the median eminence contained vasopressin (AVP) and AVP precursor-derived peptides coexistent in the same secretory vesicles as CRF. The other 50% of the CRF axons contained little or no detectable AVP or AVP precursor-derived peptides. Differential activation of these subpopulations of CRF axons could provide a mechanism by which levels of CRF and AVP in portal plasma could be varied independently.
连续超薄切片的电子显微镜免疫细胞化学显示，在正常大鼠中，正中隆起外侧区约50%的促肾上腺皮质激素释放因子（CRF）轴突含有血管加压素（AVP）以及与CRF共存于相同分泌囊泡中的AVP前体衍生肽。其余50%的CRF轴突几乎不含或未检测到AVP或AVP前体衍生肽。这些CRF轴突亚群的差异性激活可能提供一种机制，通过该机制门静脉血浆中CRF和AVP的水平可以独立变化。
