Suppes T, Pinnock R D
Neuropharmacology. 1987 Apr;26(4):331-7. doi: 10.1016/0028-3908(87)90185-7.
The activity of neurones in the substantial nigra and ventral tegmentum was recorded extracellularly in vitro. Dopamine produced depression of spontaneous firing in a dose-dependent manner. Antagonism of these neuronal responses to dopamine by metoclopramide, SCH 23390 and clozapine was examined. Metoclopramide antagonised the responses to dopamine in the manner expected; SCH 23390 had little effect on the response to dopamine as would be predicted for a selective dopamine "D1" antagonist. Clozapine did not produce the expected antagonism of the response to dopamine. The results at the single neurone level are compared with behavioural and biochemical data.
在体外对黑质和腹侧被盖区的神经元活动进行了细胞外记录。多巴胺以剂量依赖的方式抑制自发放电。研究了甲氧氯普胺、SCH 23390和氯氮平对这些神经元对多巴胺反应的拮抗作用。甲氧氯普胺以预期的方式拮抗对多巴胺的反应；正如选择性多巴胺“D1”拮抗剂所预测的那样，SCH 23390对多巴胺反应几乎没有影响。氯氮平并未产生预期的对多巴胺反应的拮抗作用。将单个神经元水平的结果与行为和生化数据进行了比较。
