hypermethylation promotes cell proliferation and metastasis in breast cancer.

The methylation and expression levels of in breast cancer were investigated and their effects on tumor cells were researched. Bioinformatics was employed to identify the target gene from TCGA database. Sodium bisulfite and decitabine were used for DNA modification and demethylation, and methylation-specific PCR and reverse transcriptase PCR were performed to assess methylation and expression levels. Tumor cell behaviors were assayed via several experiments. was hypermethylated, which caused its poor expression in breast cancer, whereas its overexpression significantly suppressed cancer cell proliferation, migration and invasion and induced apoptosis. negatively functions in cancer progression upon overexpression, indicating its potential as a therapeutic target for clinical treatment of breast cancer.