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中成药联合常规西药治疗新型冠状病毒肺炎(COVID-19)的疗效:一项系统评价与Meta分析方案

The therapeutic efficacy of Chinese patent medicine combined with routine western medicine in the treatment of coronavirus disease 2019 (COVID-19): A protocol for systematic review and meta-analysis.

作者信息

Zhang Jingxia, Li Shasha, Zhao Chongbo, Wang Weifeng, Li Fan, Li Fang

机构信息

Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang.

Shaanxi Academy of Traditional Chinese Medicine, Xi'an, Shaanxi, China.

出版信息

Medicine (Baltimore). 2020 Sep 18;99(38):e22277. doi: 10.1097/MD.0000000000022277.

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) is a potentially fatal disease. clinical practice shows that Chinese Patent Medicine (CPM) has played an important role in the outbreak, Among them, Jinhua Qinggan granules, Lianhua Qingwen capsule, and Xuebiqing injection have an effect in treating COVID-19 patients, but it has not been systematically evaluated for efficacy and safety. We provide a protocol for systematic review and meta-analysis.

MATERIALS AND METHODS

Retrieved the database, including the China National Knowledge Infrastructure, Chinese Biomedical Database, Wan Fang database, and PubMed. The quality of each study is assessed according to the criteria of the Cochrane Handbook for Systematic Reviews of Interventions. Using Manager 5.3 software and STATA 16.0 software were used to perform the meta-analysis.

RESULTS

The systematic review and meta-analysis aims to review and pool current clinical outcomes of CPM combined with routine western medicine (RWM) for the treatment of COVID-19.

CONCLUSION

This study will provide evidence of CPM (including Jinhua Qinggan granule, Lianhua Qingwen capsule, and Xuebiqing injection) for the treatment on COVID-19 patients.INPLASY Registration number: INPLASY202050050.

摘要

背景

2019年冠状病毒病(COVID-19)是一种潜在的致命疾病。临床实践表明,中成药在此次疫情中发挥了重要作用,其中金花清感颗粒、连花清瘟胶囊和血必净注射液对治疗COVID-19患者有一定效果,但尚未对其疗效和安全性进行系统评价。我们提供一项系统评价和荟萃分析的方案。

材料与方法

检索中国知网、中国生物医学数据库、万方数据库和PubMed等数据库。根据Cochrane干预措施系统评价手册的标准评估每项研究的质量。使用RevMan 5.3软件和STATA 16.0软件进行荟萃分析。

结果

该系统评价和荟萃分析旨在回顾和汇总中成药联合常规西药治疗COVID-19的当前临床结局。

结论

本研究将为中成药(包括金花清感颗粒、连花清瘟胶囊和血必净注射液)治疗COVID-19患者提供证据。INPLASY注册号:INPLASY202050050。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/373b/7505289/32ccda8ef8cc/medi-99-e22277-g001.jpg

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