Unit of Allergy, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy -
Unit of Pediatric Cardiology, Meyer Children's University Hospital, Florence, Italy.
Minerva Pediatr. 2020 Oct;72(5):383-392. doi: 10.23736/S0026-4946.20.06007-7. Epub 2020 Sep 22.
Kounis Syndrome is defined as a hypersensitivity coronary disorder constituted by the association of an acute coronary syndrome with a hypersensitivity, allergic, anaphylactic or anaphylactoid reaction, in a pathophysiologic context involving mast-cells, platelets, eosinophils and various interacting inflammatory cells. Currently, Kounis Syndrome is established in the literature, as accompanied by a plethora of clinical case reports that further elucidate its aspects. To the best of our knowledge, a specific analysis regarding the pediatric data of Kounis Syndrome has never been performed. The aim of this review was to reveal all the pediatric Kounis Syndrome cases in the literature, in an attempt to define its clinical implications in children. Moreover, based on the data of this analysis, a new classification for Kounis Syndrome is proposed, focusing mainly in the presence or the absence of allergic myocardial infarction, as the central clinical feature for the stratification of the patients' clinical manifestations.
库恩斯综合征被定义为一种过敏相关性冠状动脉疾病，其特点是在涉及肥大细胞、血小板、嗜酸性粒细胞和各种相互作用的炎症细胞的病理生理背景下，急性冠状动脉综合征与过敏、过敏样、过敏或过敏反应相关联。目前，库恩斯综合征在文献中已经确立，并有大量的临床病例报告进一步阐明了其各个方面。据我们所知，从未对库恩斯综合征的儿科数据进行过专门分析。本综述的目的是揭示文献中所有儿科库恩斯综合征的病例，试图确定其在儿童中的临床意义。此外，基于这项分析的数据，提出了一种新的库恩斯综合征分类方法，主要侧重于是否存在过敏性心肌梗死，因为这是对患者临床表现进行分层的核心临床特征。
