Ragona R, Anglesio S, Urgesi A, Monetti U, Rossi G, Tessa M
Radiol Med. 1987 May;73(5):438-42.
Total body irradiation (TBI) is used in our Institution in the conditioning regimen for bone marrow transplantation. The fractionation pattern consists of two daily fractions of 1.65 Gy repeated for 4 days (total dose 13.20 Gy in 8 fractions). Lung dose is reduced by means of lead custom shaped shields directly strapped to the patient surface. TBI is delivered by a THERAC 20 linear accelerator with two opposing AP-PA photon beams with a maximum energy of 18 MeV. Treatment distance is 340 cm and the patient is treated in a semi-standing position. Dosimetry studies in a homogeneous phantom were performed in the treatment geometry and consisted in the determination of: tissue maximum ratios (TMR) at different depths, absorbed dose along the median axis and the diagonal of the field, variation of the absorbed dose in the prescription point with different volumes of scattering material, and transmission of shielding and compensating material. A semi-empiric formula for the calculation of absorbed dose in a point has been obtained. A subsequent study in a Rando phantom with termoluminescent dosimeters (TLD) has shown a +/- 5% agreement between calculated and measured values and a +/- 7% homogeneity.
全身照射(TBI)在我们机构用于骨髓移植的预处理方案中。分割模式为每天两次,每次1.65 Gy,重复4天(8次分割的总剂量为13.20 Gy)。通过直接绑在患者体表的定制铅屏蔽来降低肺部剂量。TBI由一台THERAC 20直线加速器提供,采用两个相对的前后对穿光子束,最大能量为18 MeV。治疗距离为340 cm,患者以半站立姿势接受治疗。在治疗几何条件下,在均匀体模中进行了剂量学研究,包括测定不同深度处的组织最大剂量比(TMR)、沿射野中轴线和对角线的吸收剂量、不同散射材料体积下处方点吸收剂量的变化以及屏蔽和补偿材料的透射率。得到了一个用于计算某点吸收剂量的半经验公式。随后在带有热释光剂量计(TLD)的朗多体模中进行的研究表明,计算值与测量值之间的一致性为±5%,均匀性为±7%。