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应用活体亲属提供的新鲜头皮移植物治疗儿童大面积深度烧伤:7 年以上临床研究。

Use of Fresh Scalp Allografts From Living Relatives for Extensive Deep Burns in Children: A Clinical Study Over 7 Years.

机构信息

Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.

出版信息

J Burn Care Res. 2021 Mar 4;42(2):323-330. doi: 10.1093/jbcr/iraa155.

Abstract

Conventionally, pediatric patients with major burns need frozen cadaveric allografts to save their lives. However, these allografts are insufficient in many burn units because of cultural and local governmental laws in China. This paper reported 22 pediatric patients with major burns who received fresh scalp allografts from their parents, siblings, or relatives from January 2011 to December 2017. These 22 pediatric patients sustained deep partial-thickness to full-thickness burns involving 40% total body surface area (TBSA) on average. Wounds were covered with fresh scalp allografts alone or with postage stamp autografts and fresh scalp allografts post excision. Data were collected from medical files of the treated patients, including sex, age, etiology of burn injury, abbreviated burn severity index (ABSI), and TBSA. Postoperative variables included early survival rate of skin grafts, mean time to rejection, length of hospital stay (LHS), healing time of donor sites, and follow-up complications of donors. The 1-year survival rate of the 22 pediatric patients included into the study was 100%. The early survival rate of the scalp allografts was similar to the autografts. The mean time to rejection was 15.5 ± 3.60 days. The average LHS was 58 days. All donor sites healed within 7.6 days on average, without scar formation, alopecia areata, or folliculitis. Following up data of the donors revealed a full psychological sense of accomplishment and no regrets of donating the scalp to save the burned children. Therefore, the use of fresh scalp allografts is a feasible alternative to save pediatric patients with major burns when frozen allografts are unavailable.

摘要

传统上,患有大面积烧伤的儿科患者需要冷冻的尸体同种异体移植物才能挽救生命。然而,由于中国的文化和地方政府法规,许多烧伤病房同种异体移植物都不足。本文报道了 2011 年 1 月至 2017 年 12 月期间,22 名患有大面积烧伤的儿科患者接受了来自父母、兄弟姐妹或亲属的新鲜头皮同种异体移植物。这 22 名儿科患者平均遭受深Ⅱ度至Ⅲ度烧伤,烧伤面积为 40%总体表面积(TBSA)。创面单独或邮票皮片移植联合新鲜头皮同种异体移植物切除后覆盖新鲜头皮同种异体移植物。从治疗患者的病历中收集数据,包括性别、年龄、烧伤原因、简化烧伤严重指数(ABSI)和 TBSA。术后变量包括皮肤移植物的早期存活率、排斥平均时间、住院时间(LHS)、供区愈合时间和供区随访并发症。纳入研究的 22 名儿科患者的 1 年存活率为 100%。头皮同种异体移植物的早期存活率与自体皮片相似。排斥平均时间为 15.5±3.60 天。平均 LHS 为 58 天。所有供区平均 7.6 天愈合,无瘢痕形成、斑秃或毛囊炎。供者的随访资料显示,供者完全有成就感,对捐献头皮拯救烧伤儿童没有遗憾。因此,当冷冻同种异体移植物不可用时,使用新鲜头皮同种异体移植物是挽救大面积烧伤儿科患者的可行替代方法。

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