天然产物药物发现的策略与技术。

The strategies and techniques of drug discovery from natural products.

机构信息

Beijing Key Laboratory of Drug Target Research and Drug Screening, State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; General Office, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

出版信息

Pharmacol Ther. 2020 Dec;216:107686. doi: 10.1016/j.pharmthera.2020.107686. Epub 2020 Sep 19.

DOI:10.1016/j.pharmthera.2020.107686

PMID:32961262

Abstract

Natural products have been the main sources of new drugs. The different strategies have been developed to find the new drugs based on natural products. The traditional and ethic medicines have provided information on the therapeutic effects and resulted in some notable drug discovery of natural products. The special activities of the medicine plants such as the side effects have inspired scientists to develop the novel small molecular. The microorganisms and the endogenous active substances from human or animal also become the important approaches to the drug discovery. The tremendous progress in technology led to the new strategies in drug discovery from natural products. The bioinformation and artificial intelligence have facilitated the research and development of natural products. We will provide a scene of strategies and technologies for drug discovery from natural products in this review.

摘要

天然产物一直是新药的主要来源。为了从天然产物中寻找新药，已经开发了不同的策略。传统药物和民族药物为治疗效果提供了信息，并促成了一些显著的天然产物药物发现。药用植物的特殊活性，如副作用，激发了科学家开发新型小分子。微生物和来自人类或动物的内源性活性物质也成为药物发现的重要途径。技术的巨大进步带来了从天然产物中发现新药的新策略。生物信息学和人工智能促进了天然产物的研究与开发。我们将在这篇综述中为天然产物药物发现的策略和技术提供一个场景。