Magnússon J, Tranberg K G
Scand J Gastroenterol. 1987 Apr;22(3):301-7. doi: 10.3109/00365528709078595.
This study aimed at determining the release and action of insulin in liver cirrhosis. Eight non-diabetic patients with alcoholic liver cirrhosis and eight age-, sex-, and weight-matched controls were investigated. The clearance and hypoglycemic action of insulin were determined after a brief intravenous infusion of insulin (10 mU/kg). Glucose tolerance and insulin response were determined after rapid intravenous infusion of 25 g glucose. In the cirrhotic patients the decrease in glucose tolerance was associated with a) an unchanged insulin clearance, b) a decreased hypoglycemic action of insulin, and c) a marked impairment in the early insulin response and a slight, but not significant, increase in the late insulin response. In the cirrhotic group glucose tolerance varied with the early (and late) insulin response and with the hypoglycemic action of insulin. It is concluded that both insulin action and the early insulin response are impaired in alcoholic liver cirrhosis and that deterioration of the early insulin release plays an important role for deterioration of glucose tolerance.
本研究旨在确定肝硬化患者胰岛素的释放及作用情况。对8例非糖尿病酒精性肝硬化患者及8例年龄、性别、体重匹配的对照者进行了研究。在短暂静脉输注胰岛素（10 mU/kg）后，测定胰岛素的清除率及降血糖作用。在快速静脉输注25 g葡萄糖后，测定葡萄糖耐量及胰岛素反应。肝硬化患者葡萄糖耐量降低与以下情况有关：a）胰岛素清除率未变；b）胰岛素降血糖作用降低；c）早期胰岛素反应明显受损，晚期胰岛素反应略有增加但不显著。在肝硬化组中，葡萄糖耐量随早期（及晚期）胰岛素反应以及胰岛素降血糖作用而变化。得出的结论是，酒精性肝硬化患者胰岛素作用及早期胰岛素反应均受损，早期胰岛素释放的恶化对葡萄糖耐量的恶化起重要作用。
