Sainz Talía, Delgado Jaime, Mendez-Echevarría Ana, Santiago Begoña, Lopez-Varela Elisa, Aguilera-Alonso David, Saavedra-Lozano Jesús, Rodríguez-Fernández Rosa, Holguín África, Navarro Marisa L, Muñoz-Fernández María Ángeles, Rivero-Calle Irene, Solana María José, López-Herce Jesús, Calvo Cristina
Hospital La Paz and La Paz Research Intitute (IdiPAZ), Madrid, Spain.
The Traslational Research Network of Pediatric Infectious Diseases (RITIP), Madrid, Spain.
Acta Paediatr. 2021 Feb;110(2):441-449. doi: 10.1111/apa.15578. Epub 2020 Nov 10.
In recent years, the field of infectious diseases has been hit by the overwhelming amount of information generated while the human microbiome is being disentangled. Based on the interaction between the microbiota and the immune system, the implications regarding infectious diseases are probably major and remain a challenge.
This review was conceived as a comprehensive tool to provide an overview of the available evidence regarding the influence of the microbiome on infectious diseases in children.
We present the main findings aroused from microbiome research in prevention, diagnosis and treatment of infectious disease under a paediatric perspective, to inform clinicians of the potential relevance of microbiome-related knowledge for translation to clinical practice.
The evidence shown in this review highlights the numerous research gaps ahead and supports the need to move forward to integrating the so-called microbiome thinking into our routine clinical practice.
近年来，随着人类微生物组的奥秘逐渐被解开，传染病领域受到了海量信息的冲击。基于微生物群与免疫系统之间的相互作用，其对传染病的影响可能很大，并且仍然是一个挑战。
本综述旨在作为一个综合工具，概述有关微生物组对儿童传染病影响的现有证据。
我们从儿科角度介绍微生物组研究在传染病预防、诊断和治疗方面的主要发现，以便让临床医生了解微生物组相关知识转化为临床实践的潜在相关性。
本综述中展示的证据凸显了前方众多的研究空白，并支持将所谓的微生物组思维融入我们日常临床实践的必要性。
