Kim Hyun-Jin, Jo Sang-Ho, Lee Min-Ho, Seo Won-Woo, Baek Sang Hong
Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul 04763, Korea.
Division of Cardiology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang-si 14068, Korea.
J Clin Med. 2020 Sep 19;9(9):3020. doi: 10.3390/jcm9093020.
Vasospastic angina (VA) is a functional disease caused by the alteration of vasomotor tone. We investigated the association of hyperthyroidism with the development and prognosis of VA. Study data were obtained from a prospective multicenter registry that included patients who had symptoms suggestive of VA. Coronary angiography and an ergonovine provocation test were performed, and patients were classified into a VA and a non-VA group. Among 1239 patients with suspected VA, 831 patients were classified in the VA group. Hyperthyroidism was more common in the VA group than in the non-VA group (10.0% vs. 3.7%, < 0.001). After adjusting for confounding factors, hyperthyroidism was independently associated with a 3.27-fold increased risk of VA. Especially in women, hyperthyroidism was associated with a 4.38-fold higher risk of VA. All-cause death rates did not differ according to the presence or absence of hyperthyroidism. Hyperthyroidism is independently associated with the occurrence of VA especially in women but did not affect the total death in VA patients. Clinicians need to be aware of the role of thyroid function in patients with suspected VA.
变异性心绞痛（VA）是一种由血管运动张力改变引起的功能性疾病。我们研究了甲状腺功能亢进与VA发生及预后的关系。研究数据来自一个前瞻性多中心登记处，该登记处纳入了有VA症状提示的患者。进行了冠状动脉造影和麦角新碱激发试验，患者被分为VA组和非VA组。在1239例疑似VA患者中，831例患者被分类为VA组。VA组甲状腺功能亢进比非VA组更常见（10.0%对3.7%，<0.001）。在调整混杂因素后，甲状腺功能亢进与VA风险增加3.27倍独立相关。尤其是在女性中，甲状腺功能亢进与VA风险高4.38倍相关。甲状腺功能亢进与否，全因死亡率无差异。甲状腺功能亢进尤其在女性中与VA的发生独立相关，但不影响VA患者的总死亡率。临床医生需要意识到甲状腺功能在疑似VA患者中的作用。
