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Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer.在临床前和临床研究中抑制抗凋亡 Bcl-2 蛋白：癌症的当前概述。
Cells. 2020 May 21;9(5):1287. doi: 10.3390/cells9051287.
2
Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies.用 BH3 模拟物恢复成熟 B 细胞恶性肿瘤中的细胞凋亡。
Cells. 2020 Mar 14;9(3):717. doi: 10.3390/cells9030717.
3
Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions.Bcl-xL 的构象转变：使非典型凋亡抑制作用成为可能涉及多个中间体和脂相互作用。
Cells. 2020 Feb 26;9(3):539. doi: 10.3390/cells9030539.
4
HOXA9 Transcriptionally Promotes Apoptosis and Represses Autophagy by Targeting NF-κB in Cutaneous Squamous Cell Carcinoma.HOXA9 通过靶向 NF-κB 在皮肤鳞状细胞癌中促进细胞凋亡并抑制自噬。
Cells. 2019 Oct 31;8(11):1360. doi: 10.3390/cells8111360.
5
The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study.去泛素化酶抑制剂 PR-619 通过抑制抗凋亡 Bcl-2 蛋白增强顺铂的细胞毒性：体外和体内研究。
Cells. 2019 Oct 17;8(10):1268. doi: 10.3390/cells8101268.
6
The Incomplete Puzzle of the BCL2 Proteins.BCL2 蛋白的未解之谜。
Cells. 2019 Sep 29;8(10):1176. doi: 10.3390/cells8101176.

Bcl-2 家族蛋白对细胞凋亡的调控：处于边缘的领域。

Regulation of Apoptosis by the Bcl-2 Family of Proteins: Field on a Brink.

机构信息

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

出版信息

Cells. 2020 Sep 18;9(9):2121. doi: 10.3390/cells9092121.

DOI:10.3390/cells9092121
PMID:32961920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7564874/
Abstract

Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...].

摘要

细胞凋亡是一种程序性细胞死亡形式，是组织发育、内稳态和各种疾病发病机制的关键，是一个高度调控的过程[...]。