Department of Internal Medicine, Daegu Catholic University Medical Center, Daegu Catholic University School of Medicine, 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu, 42472, South Korea.
BMC Pulm Med. 2020 Sep 22;20(1):252. doi: 10.1186/s12890-020-01292-7.
Secondary organizing pneumonia (SOP) is difficult to distinguish from cryptogenic organizing pneumonia (COP) considering various clinical situations. SOP caused by Mycobacterium tuberculosis is rare; indeed, it has not been reported as a sequela of disseminated tuberculosis.
From January 2016 to December 2018, we identified six cases of tuberculosis-associated SOP in which Mycobacterium tuberculosis was revealed by microbiological examination; one of the cases was miliary tuberculosis.
Of the six cases, 17% were positive for acid fast bacillus (AFB) stain, but 100% were positive for M. tuberculosis polymerase chain reaction (MTB PCR) and AFB culture. In all cases, transbronchial lung biopsy was performed and organizing pneumonia was confirmed pathologically. All survived after treatment with anti-tuberculosis therapy.
Pulmonary tuberculosis, which shows OP in lung biopsy, is diagnosed through MTB PCR and AFB culture, and the prognosis is thought to be good.
继发性机化性肺炎（SOP）在考虑各种临床情况时，难以与隐源性机化性肺炎（COP）区分。由结核分枝杆菌引起的 SOP 很少见；事实上，它尚未被报道为播散性结核病的后遗症。
从 2016 年 1 月至 2018 年 12 月，我们发现了六例由微生物检查证实的与结核分枝杆菌相关的 SOP 病例；其中一例为粟粒性肺结核。
六例中，17%的病例抗酸杆菌（AFB）染色阳性，但 100%的病例结核分枝杆菌聚合酶链反应（MTB PCR）和 AFB 培养阳性。所有病例均行经支气管肺活检，组织学证实为机化性肺炎。所有患者均经抗结核治疗后存活。
通过 MTB PCR 和 AFB 培养诊断肺活检显示 OP 的肺结核，其预后被认为良好。
