Marrs T C, Bright J E, Morris B C
Toxicol Lett. 1987 May;36(3):281-7. doi: 10.1016/0378-4274(87)90197-4.
Single doses of primaquine did not produce methemoglobinemia in beagle bitches. Repeated daily administration for 12 days produced a gradually rising level of methemoglobin over that time period, unaccompanied by depletion of erythrocytic reduced glutathione. Primaquine was mutagenic in the Ames test in Salmonella typhimurium strain TA 1537, with or without S9, using a liquid preincubation assay. Primaquine was non-mutagenic in this assay to strains TA 1535, TA 1538, TA 98 and TA 100, regardless of the presence or absence of S9. In the standard overpour Ames test, the drug was non-mutagenic in all 5 Salmonella strains, both with and without S9 metabolic activation.
单剂量伯氨喹未在比格犬中引起高铁血红蛋白血症。连续12天每日重复给药，在此期间高铁血红蛋白水平逐渐升高，同时红细胞内还原型谷胱甘肽未出现消耗。在鼠伤寒沙门氏菌TA 1537菌株的Ames试验中，无论有无S9，采用液体预孵育试验时，伯氨喹具有致突变性。在该试验中，无论有无S9，伯氨喹对TA 1535、TA 1538、TA 98和TA 100菌株均无致突变性。在标准倾注平板Ames试验中，无论有无S9代谢激活，该药物在所有5种沙门氏菌菌株中均无致突变性。
