Nwankwo Theophilus Ogochukwu, Umeh Uchenna Anthony, Aniebue Uzochukwu Uzoma, Onu Justus Uchenna, Umeh Chioma Roseline
Department of Obstetrics and Gynecology, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria.
Department of Mental Health, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria.
Pan Afr Med J. 2020 Jul 23;36:210. doi: 10.11604/pamj.2020.36.210.24141. eCollection 2020.
There is paucity of data on interventions to improve cancer outcome in the low-resource setting. This study aims to determine the effect of Neoadjuvant Chemotherapy (NACT) in improving operative outcomes of cervical cancer. This was a longitudinal intervention study of patients diagnosed with FIGO stage IIB - IIIA cervical cancer that had NACT. Patients were re-evaluated after treatment with 4 cycles of chemotherapy for operability. McNemar test was used to determine changes in operability of the tumour. There was a significant difference in the number of patients that converted from inoperable to operable tumor post-chemotherapy. This study shows some promise for NACT for FIGO stage IIB - IIIA cancer of the cervix, especially in low-resource settings, where radiotherapy is scarce.
在资源匮乏地区，关于改善癌症治疗结果的干预措施的数据很少。本研究旨在确定新辅助化疗（NACT）对改善宫颈癌手术结果的效果。这是一项对被诊断为FIGO IIB - IIIA期宫颈癌且接受了NACT的患者进行的纵向干预研究。患者在接受4个周期化疗后重新评估手术可行性。采用McNemar检验来确定肿瘤手术可行性的变化。化疗后肿瘤从不可切除转变为可切除的患者数量有显著差异。本研究表明，NACT对FIGO IIB - IIIA期宫颈癌有一定前景，尤其是在放疗资源稀缺的低资源地区。
