Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, 6229, Maastricht, The Netherlands.
Luxembourg Centre for Systems Biomedicine, Université du Luxembourg, 6 Avenue du Swing, L-4367, Belvaux, Luxembourg.
Curr Heart Fail Rep. 2020 Dec;17(6):357-364. doi: 10.1007/s11897-020-00489-5. Epub 2020 Sep 23.
In the last decade, cardio-oncology has become a discipline on its own, with tremendous research going on to unravel the mechanisms underpinning different manifestations of cardiotoxicity caused by anticancer drugs. Although this domain is much broader than the effect of chemotherapy alone, a lot of questions about anthracycline-induced cardiotoxicity remain unknown. In this invited review, we provide insights in molecular mechanisms behind anthracycline-induced cardiotoxicity and put it in a clinical framework emphasizing the need for patients to understand, detect, and treat this detrimental condition.
在过去的十年中，肿瘤心脏病学已经成为一个独立的学科，大量的研究正在进行，以揭示抗癌药物引起的不同类型心脏毒性的机制。尽管这一领域比单纯的化疗影响广泛得多，但关于蒽环类药物引起的心脏毒性仍有许多未知问题。在这篇特邀评论中，我们深入探讨了蒽环类药物引起的心脏毒性的分子机制，并将其置于一个临床框架中，强调了患者了解、检测和治疗这种有害疾病的必要性。
