Division of Transfusion Science, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Department of Ophthalmology, Faculty of Medicines, Chiang Mai University, Chiang Mai, Thailand.
Ocul Immunol Inflamm. 2021 Feb 17;29(2):260-263. doi: 10.1080/09273948.2020.1813315. Epub 2020 Sep 23.
To determine the frequency and association of alleles at human leukocyte antigen (HLA)- and loci in VKH disease patients from Northern Thailand.
A case-control study was conducted with three subject groups: 23 VKH patients, 20 patients with other uveitis entities, and 40 healthy blood donors. and loci were analyzed and the frequency of and alleles was calculated by direct counting. The measure of association was calculated by odds ratio (OR) and 95% confidence interval.
In VKH patients, the most prevalent allele was , found in 35% of patients and with the highest OR (42.13). was the next most prevalent, found in 23.91% of VKH patients. was also detected in 23.91% of patients; however, a higher prevalence was observed in non-VKH and healthy controls (30% and 35%, respectively).
and could be potential genetic markers for VKH.
在来自泰国北部的 VKH 病患者中确定人类白细胞抗原（HLA）- 和 位点等位基因的频率和相关性。
进行了一项病例对照研究，共有三组研究对象：23 名 VKH 患者、20 名患有其他葡萄膜炎的患者和 40 名健康献血者。分析了 和 位点，并通过直接计数计算了 和 等位基因的频率。关联的度量通过优势比（OR）和 95%置信区间计算。
在 VKH 患者中，最常见的等位基因是 ，在 35%的患者中发现，具有最高的 OR（42.13）。 是下一个最常见的，在 23.91%的 VKH 患者中发现。 也在 23.91%的患者中检测到；然而，在非 VKH 和健康对照组中观察到更高的患病率（分别为 30%和 35%）。
和 可能是 VKH 的潜在遗传标记。
