Sklyarova V, Kyshakevych I, Volosovsky P, Sklyarov P, Kupchak I
1Danylo Halytskyi Lviv National Medical University; 3Lviv City Center for Family Planning and Human Reproduction, Ukraine.
2Ivano-Frankivsk National Medical University; Ukraine.
Georgian Med News. 2020 Jul-Aug(304-305):27-32.
Сhronic endometritis is a medical and social problem that leads to impaired reproductive health of women. Even after elimination of the causative agent of inflammation detect changes in the endometrium by determining immunohistochemical markers (СD 138). The purpose of this study is to analyze the incidence of chronic endometritis in women of reproductive age with reproductive health disorders.; We performed hysteroscopy and determination СD 138 30 patients with recurrent pregnancy loss, 47 women with primary infertility and 36 women who applied for a pregnancy planning examination and endometrial polyps detected during routine ultrasound. In patients with habitual miscarriage, primary infertility, and women in the planning of pregnancy and endometrial polyps, a high frequency of bacterial vaginosis and recurrent inflammatory diseases of the lower parts of the reproductive system was noted (p>0.01). In the study of infectious agents of the lower parts of the reproductive system of patients of all groups found in the pathological growth of ureoplasmic infection and a group of non-specific infections (Enterococcus faecalis, Esherichia coli, Proteus sp, Klebsiella sp, S. aureus, agactactia) (p>0.05). Hysteroscopic changes in endometrial pathology were present in 57% of women with habitual miscarriage and primary infertility (p>0.05). In immunohistochemical examination of the endometrium, chronic endometritis was diagnosed in 80% of patients with habitual miscarriage, in 55% of women with primary infertility and in 61% of women when planning pregnancy and polyps of the endometrium (p>0.01).
慢性子宫内膜炎是一个医学和社会问题，会导致女性生殖健康受损。即使在消除炎症病原体后，通过测定免疫组化标志物（CD 138）仍可检测到子宫内膜的变化。本研究的目的是分析患有生殖健康障碍的育龄妇女慢性子宫内膜炎的发病率。我们对30例复发性流产患者、47例原发性不孕妇女以及36例申请妊娠计划检查且在常规超声检查中发现子宫内膜息肉的妇女进行了宫腔镜检查并测定CD 138。在习惯性流产患者、原发性不孕妇女以及计划妊娠且有子宫内膜息肉的妇女中，细菌性阴道病和生殖系统下部复发性炎症疾病的发生率较高（p>0.01）。在对所有组患者生殖系统下部感染病原体的研究中，发现脲原体感染和一组非特异性感染（粪肠球菌、大肠埃希菌、变形杆菌属、克雷伯菌属、金黄色葡萄球菌、无乳链球菌）呈病理性增长（p>0.05）。57%的习惯性流产和原发性不孕妇女存在宫腔镜下子宫内膜病理改变（p>0.05）。在子宫内膜免疫组化检查中，80%的习惯性流产患者、55%的原发性不孕妇女以及61%计划妊娠且有子宫内膜息肉的妇女被诊断为慢性子宫内膜炎（p>0.01）。
