Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Brno, Czech Republic.
First Department of Neurology, Medical Faculty of Masaryk University, Movement Disorders Center, Masaryk University School of Medicine, St. Anne's Hospital, Pekařská 53, 656 91, Brno, Czech Republic.
J Neural Transm (Vienna). 2020 Dec;127(12):1579-1588. doi: 10.1007/s00702-020-02254-3. Epub 2020 Sep 23.
Although deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) is generally a successful therapy, adverse events and insufficient clinical effect can complicate the treatment in some patients. We studied clinical parameters and cortical oscillations related to STN-DBS to identify patients with suboptimal responses. High-density EEG was recorded during a visual oddball three-stimuli paradigm in DBS "off" and "on" conditions in 32 PD patients with STN-DBS. Pre-processed data were reconstructed into the source space and the time-frequency analysis was evaluated. We identified a subgroup of six patients with longer reaction times (RT) during the DBS "on" state than in the DBS "off" state after target stimuli. These subjects had lower motor responsiveness to DBS and decreased memory test results compared to the other subjects. Moreover, the alpha and beta power decrease (event-related desynchronizations, ERD), known as an activation correlate linked to motor and cognitive processing, was also reduced in the DBS "on" condition in these patients. A subgroup of PD patients with a suboptimal response to STN-DBS was identified. Evaluation of RT could potentially serve as a biomarker for responsiveness to STN-DBS.
尽管丘脑底核（STN）深部脑刺激（DBS）在帕金森病（PD）中通常是一种成功的治疗方法，但在一些患者中，不良反应和临床效果不足会使治疗变得复杂。我们研究了与 STN-DBS 相关的临床参数和皮质振荡，以确定对治疗反应不佳的患者。在 32 名接受 STN-DBS 的 PD 患者的 DBS“关闭”和“开启”状态下，我们使用高密度 EEG 记录了视觉Oddball 三刺激范式。对预处理后的数据进行了源空间重建，并对时频分析进行了评估。我们发现有 6 名患者在目标刺激后，DBS“开启”状态下的反应时间（RT）长于 DBS“关闭”状态。与其他患者相比，这些患者对 DBS 的运动反应性较低，记忆测试结果也较差。此外，在这些患者中，与运动和认知处理相关的激活相关的 alpha 和 beta 功率降低（事件相关去同步化，ERD）也减少了。我们确定了对 STN-DBS 反应不佳的 PD 患者亚组。评估 RT 可能成为对 STN-DBS 反应的生物标志物。
