炎症性饮食模式与肾移植受者角质形成细胞癌的风险：前瞻性队列研究。

Inflammatory Dietary Patterns and Risk of Keratinocyte Cancers in Kidney Transplant Recipients: Prospective Cohort Study.

机构信息

QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia,

Faculty of Medicine, The University of Queensland, St Lucia, Queensland, Australia,

出版信息

Dermatology. 2021;237(6):1029-1034. doi: 10.1159/000509875. Epub 2020 Sep 23.

DOI:10.1159/000509875

PMID:32966976

Abstract

BACKGROUND

Kidney transplant recipients (KTRs) are at increased risk of cutaneous squamous (SCC) and basal cell carcinomas (BCC) due to immunosuppression and sun exposure. Skin carcinogenesis involves inflammation, and foods that promote inflammation may promote carcinogenesis.

METHODS

We prospectively examined the association between pro-inflammatory diets and SCC and BCC incidence in KTRs in Queensland, Australia. We recruited KTRs at high risk of skin cancer (aged ≥18 years and previously affected; or aged ≥40; or immunosuppressed ≥10 years) between 2012 and 2014 and followed up until June 2016. A baseline dietary questionnaire was used to calculate modified-Empirical Dietary Inflammatory Pattern (EDIP) scores to indicate dietary inflammatory capacity; higher scores indicated pro-inflammatory diets. EDIP scores were ranked into 3 groups. Outcomes were histologically confirmed SCC and BCC. Adjusted relative risks (RRadj) and 95% CIs were estimated using negative binomial regression.

RESULTS

Among 260 KTRs, 100 (38%) and 93 (36%) developed at least 1 new SCC and BCC, with 426 SCC and 343 BCC diagnosed in the follow-up period. The highest modified-EDIP score group (vs. lowest) were at increased risk of SCC (RRadj 1.79, 95% CI 1.01-3.16) but not BCC. Pro-inflammatory diets may increase SCC but not BCC risk among KTRs.

CONCLUSIONS

Inflammatory diets may increase the risk of SCC in KTRs.

摘要

背景

由于免疫抑制和阳光暴露，肾移植受者（KTR）患皮肤鳞状细胞癌（SCC）和基底细胞癌（BCC）的风险增加。皮肤癌发生涉及炎症，促进炎症的食物可能促进癌发生。

方法

我们前瞻性研究了澳大利亚昆士兰州 KTR 中促炎饮食与 SCC 和 BCC 发病率之间的关系。我们于 2012 年至 2014 年间招募了患有皮肤癌风险高的 KTR（年龄≥18 岁且以前患有皮肤癌；或年龄≥40 岁；或免疫抑制≥10 年），并随访至 2016 年 6 月。基线饮食问卷用于计算改良经验性饮食炎症模式（EDIP）评分，以指示饮食炎症能力；分数越高表明促炎饮食。EDIP 评分分为 3 组。结果为组织学证实的 SCC 和 BCC。使用负二项式回归估计调整后的相对风险（RRadj）和 95%CI。

结果

在 260 名 KTR 中，有 100 名（38%）和 93 名（36%）至少发生了 1 种新的 SCC 和 BCC，随访期间诊断出 426 例 SCC 和 343 例 BCC。最高改良 EDIP 评分组（与最低评分组相比）患 SCC 的风险增加（RRadj 1.79，95%CI 1.01-3.16），但 BCC 风险没有增加。促炎饮食可能会增加 KTR 中 SCC 但不会增加 BCC 的风险。