阿尔茨海默病和路易体痴呆症中海马亚区与日常生活活动能力下降。
Hippocampal subfields and decline in activities of daily living in Alzheimer's disease and dementia with Lewy bodies.
机构信息
Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.
Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia.
出版信息
Neurodegener Dis Manag. 2020 Dec;10(6):357-367. doi: 10.2217/nmt-2020-0039. Epub 2020 Sep 23.
Hippocampal atrophy is presented in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional decline in activities of daily living. We examined the association between baseline hippocampal subfield volumes (HSv) in mild AD and DLB, and functional decline. 12 HSv were computed from structural magnetic resonance images using Freesurfer 6.0 segmentation. Functional decline was assessed using the rapid disability rating scale score. Linear regressions were conducted. In AD, HSv were smaller bilaterally. However, HSv were not associated with functional decline. Functional decline does not depend on HSv in mild AD and DLB.
海马体萎缩存在于阿尔茨海默病（AD）和路易体痴呆（DLB）中。认知、双重任务、肌肉功能、与目标相关的行为和神经精神症状与海马体体积有关，并可能导致日常生活活动的功能下降。我们研究了轻度 AD 和 DLB 患者基线时海马亚区体积（HSv）与功能下降之间的关系。使用 Freesurfer 6.0 分割从结构磁共振图像中计算了 12 个 HSV。使用快速残疾评定量表评分评估功能下降。进行了线性回归。在 AD 中，双侧 HSV 较小。然而，HSv 与功能下降无关。在轻度 AD 和 DLB 中，功能下降不依赖于 HSV。
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