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Neuroimage. 2020 Apr 15;210:116563. doi: 10.1016/j.neuroimage.2020.116563. Epub 2020 Jan 21.
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Regional Structural Hippocampal Differences Between Dementia with Lewy Bodies and Parkinson's Disease.路易体痴呆与帕金森病的区域性结构海马差异。
J Parkinsons Dis. 2019;9(4):775-783. doi: 10.3233/JPD-191600.
3
How do impairments in cognitive functions affect activities of daily living functions in older adults?认知功能障碍如何影响老年人的日常生活活动功能？
PLoS One. 2019 Jun 7;14(6):e0218112. doi: 10.1371/journal.pone.0218112. eCollection 2019.
4
EEG Resting-State Networks in Dementia with Lewy Bodies Associated with Clinical Symptoms.帕金森病相关路易体痴呆的静息态脑电图网络与临床症状相关。
Neuropsychobiology. 2019;77(4):206-218. doi: 10.1159/000495620. Epub 2019 Jan 17.
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Participant outcomes and preferences in Alzheimer's disease clinical trials: The electronic Person-Specific Outcome Measure (ePSOM) development program.阿尔茨海默病临床试验中的参与者结局与偏好：电子个性化结局测量（ePSOM）开发项目。
Alzheimers Dement (N Y). 2018 Dec 12;4:694-702. doi: 10.1016/j.trci.2018.10.013. eCollection 2018.
6
The Contribution of Tau, Amyloid-Beta and Alpha-Synuclein Pathology to Dementia in Lewy Body Disorders.tau蛋白、β淀粉样蛋白和α-突触核蛋白病理在路易体疾病所致痴呆中的作用
J Alzheimers Dis Parkinsonism. 2018;8(4). doi: 10.4172/2161-0460.1000444. Epub 2018 Aug 10.
7
A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium.路易体痴呆症患者大脑皮质萎缩的特征性模式：来自欧洲 DLB 联盟的 333 名患者的研究。
Alzheimers Dement. 2019 Mar;15(3):400-409. doi: 10.1016/j.jalz.2018.09.011. Epub 2018 Nov 12.
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Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia.海马亚区体积与认知功能及痴呆风险的关系。
Neuroimage. 2018 Sep;178:129-135. doi: 10.1016/j.neuroimage.2018.05.041. Epub 2018 May 18.
9
A comparison of manual tracing and FreeSurfer for estimating hippocampal volume over the adult lifespan.手动追踪与 FreeSurfer 估算成年后海马体体积的比较。
Hum Brain Mapp. 2018 Jun;39(6):2500-2513. doi: 10.1002/hbm.24017. Epub 2018 Feb 21.
10
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阿尔茨海默病和路易体痴呆症中海马亚区与日常生活活动能力下降。

Hippocampal subfields and decline in activities of daily living in Alzheimer's disease and dementia with Lewy bodies.

机构信息

Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway.

Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogotá, Colombia.

出版信息

Neurodegener Dis Manag. 2020 Dec;10(6):357-367. doi: 10.2217/nmt-2020-0039. Epub 2020 Sep 23.

DOI:10.2217/nmt-2020-0039
PMID:32967534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7574162/
Abstract

Hippocampal atrophy is presented in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional decline in activities of daily living. We examined the association between baseline hippocampal subfield volumes (HSv) in mild AD and DLB, and functional decline.  12 HSv were computed from structural magnetic resonance images using Freesurfer 6.0 segmentation. Functional decline was assessed using the rapid disability rating scale score. Linear regressions were conducted. In AD, HSv were smaller bilaterally. However, HSv were not associated with functional decline. Functional decline does not depend on HSv in mild AD and DLB.

摘要

海马体萎缩存在于阿尔茨海默病（AD）和路易体痴呆（DLB）中。认知、双重任务、肌肉功能、与目标相关的行为和神经精神症状与海马体体积有关，并可能导致日常生活活动的功能下降。我们研究了轻度 AD 和 DLB 患者基线时海马亚区体积（HSv）与功能下降之间的关系。使用 Freesurfer 6.0 分割从结构磁共振图像中计算了 12 个 HSV。使用快速残疾评定量表评分评估功能下降。进行了线性回归。在 AD 中，双侧 HSV 较小。然而，HSv 与功能下降无关。在轻度 AD 和 DLB 中，功能下降不依赖于 HSV。