Zhou Jiajing, Lin Zhixing, Penna Matthew, Pan Shuaijun, Ju Yi, Li Shiyao, Han Yiyuan, Chen Jingqu, Lin Gan, Richardson Joseph J, Yarovsky Irene, Caruso Frank
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia.
School of Engineering, RMIT University, Melbourne, VIC, 3001, Australia.
Nat Commun. 2020 Sep 23;11(1):4804. doi: 10.1038/s41467-020-18589-0.
We report a facile strategy for engineering diverse particles based on the supramolecular assembly of natural polyphenols and a self-polymerizable aromatic dithiol. In aqueous conditions, uniform and size-tunable supramolecular particles are assembled through π-π interactions as mediated by polyphenols. Owing to the high binding affinity of phenolic motifs present at the surface, these particles allow for the subsequent deposition of various materials (i.e., organic, inorganic, and hybrid components), producing a variety of monodisperse functional particles. Moreover, the solvent-dependent disassembly of the supramolecular networks enables their removal, generating a wide range of corresponding hollow structures including capsules and yolk-shell structures. The versatility of these supramolecular networks, combined with their negligible cytotoxicity provides a pathway for the rational design of a range of particle systems (including core-shell, hollow, and yolk-shell) with potential in biomedical and environmental applications.
我们报道了一种基于天然多酚和可自聚合芳族二硫醇的超分子组装来设计多种颗粒的简便策略。在水性条件下，均匀且尺寸可调的超分子颗粒通过多酚介导的π-π相互作用组装而成。由于表面存在的酚基具有高结合亲和力，这些颗粒允许随后沉积各种材料（即有机、无机和杂化成分），从而产生各种单分散功能颗粒。此外，超分子网络的溶剂依赖性解组装使其能够被去除，从而产生包括胶囊和蛋黄壳结构在内的多种相应空心结构。这些超分子网络的多功能性，再加上其可忽略不计的细胞毒性，为合理设计一系列在生物医学和环境应用中具有潜力的颗粒系统（包括核壳、空心和蛋黄壳）提供了一条途径。
