Yang Mingchuan, He Yufeng, Ni Qingqing, Zhou Mengxue, Chen Hongping, Li Guangyun, Yu Jizhong, Wu Ximing, Zhang Xiangchun
Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China.
Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.
Pharmaceutics. 2024 Jul 23;16(8):972. doi: 10.3390/pharmaceutics16080972.
Cancer remains a highly lethal disease globally. The approach centered on REDOX-targeted mitochondrial therapy for cancer has displayed notable benefits. Plant polyphenols exhibit strong REDOX and anticancer properties, particularly by affecting mitochondrial function, yet their structural instability and low bioavailability hinder their utility. To overcome this challenge, researchers have utilized the inherent physical and chemical characteristics of polyphenols and their derivatives to develop innovative nanomedicines for targeting mitochondria. This review examines the construction strategies and anticancer properties of various types of polyphenol-based biological nanomedicine for regulating mitochondria in recent years, such as polyphenol self-assembly, metal-phenol network, polyphenol-protein, polyphenol-hydrogel, polyphenol-chitosan, and polyphenol-liposome. These polyphenolic nanomedicines incorporate enhanced features such as improved solubility, efficient photothermal conversion capability, regulation of mitochondrial homeostasis, and ion adsorption through diverse construction strategies. The focus is on how these polyphenol nanomedicines promote ROS production and their mechanism of targeting mitochondria to inhibit cancer. Furthermore, it delves into the benefits and applications of polyphenolic nanomedicine in cancer treatments, as well as the challenges for future research.
癌症在全球范围内仍然是一种高致死性疾病。以氧化还原靶向线粒体疗法治疗癌症的方法已显示出显著益处。植物多酚具有强大的氧化还原和抗癌特性，特别是通过影响线粒体功能，但其结构不稳定性和低生物利用度阻碍了它们的应用。为了克服这一挑战，研究人员利用多酚及其衍生物的固有物理和化学特性，开发了用于靶向线粒体的创新纳米药物。本综述探讨了近年来各种基于多酚的生物纳米药物用于调节线粒体的构建策略和抗癌特性，如多酚自组装、金属-酚网络、多酚-蛋白质、多酚-水凝胶、多酚-壳聚糖和多酚-脂质体。这些多酚纳米药物通过不同的构建策略具有增强的特性，如改善溶解性、高效的光热转换能力、调节线粒体稳态以及离子吸附。重点在于这些多酚纳米药物如何促进活性氧生成以及它们靶向线粒体抑制癌症的机制。此外，还深入探讨了多酚纳米药物在癌症治疗中的益处和应用，以及未来研究面临的挑战。
