Lazarus S C
Am Rev Respir Dis. 1987 Jun;135(6 Pt 2):S35-8. doi: 10.1164/arrd.1987.135.6P2.S35.
The airway mast cell appears to play an important role in a number of pathophysiologic responses. Mast cells may be activated directly (e.g., by specific antigen) or indirectly (e.g., by an epithelial cell product such as 15-HETE). When activated, the mast cell releases mediators that may have direct effects or indirect effects. Mast cells and mediators undoubtedly play a role in specific airway responses. The data presented here are intended to serve only as examples of the complex way in which various cells and inflammatory mediators may interact to produce a physiologic response in the airways. Possibilities exist for numerous interactions between additional mediators as well as additional cell types. Because of the complexity of the system, characterization of activation and secretion by isolated pure cells, and studies of cell-to-cell interactions in vitro appear to be important first steps toward understanding the even more complex interactions that occur in vivo.
气道肥大细胞似乎在多种病理生理反应中发挥重要作用。肥大细胞可被直接激活（如通过特异性抗原）或间接激活（如通过上皮细胞产物如15-羟基二十碳四烯酸）。激活后，肥大细胞释放的介质可能具有直接作用或间接作用。肥大细胞和介质无疑在特异性气道反应中起作用。此处呈现的数据仅旨在作为各种细胞和炎症介质相互作用以产生气道生理反应的复杂方式的示例。其他介质以及其他细胞类型之间存在众多相互作用的可能性。由于该系统的复杂性，对分离的纯细胞的激活和分泌进行表征以及体外细胞间相互作用的研究似乎是理解体内发生的更为复杂的相互作用的重要第一步。
