Department of Biology, Science College, University of Jeddah, Jeddah, Saudi Arabia.
Histol Histopathol. 2020 Dec;35(12):1437-1448. doi: 10.14670/HH-18-263. Epub 2020 Sep 24.
Cypermethrin (CYP) is an important type II pyrethroid pesticide widely used to protect crops against pests and insect infestations. However, its toxicity is a risk to both human health and the surrounding environment. The present study was conducted to investigate the nephrotoxic effect and histopathological changes caused by Cypermethrin in the kidney tissues of adult Wistar rats. In this study, 30 Wistar rats were equally divided into three groups. G1, control animals; G2 and G3 treated with various sub lethal doses of CYP for 30 days as follows: G2, administered low dose (1/100 of LD50) of CYP; G3, administered high dose (1/50 of LD50) of CYP. The damage to different organelles of renal proximal and distal cells was observed using transmission electron microscopy. Histopathological damage in kidney samples was confirmed using morphological and histological measures. The results showed that CYP caused significant histopathological damage to the renal proximal and distal tubules of treated rats. Compared to control samples, CYP caused marked alterations in the dimensions of nucleus, ovoid and filamentous mitochondria of the treated cells. In conclusion, Cypermethrin is found to be toxic to mammals. It caused marked ultrastructural damage to the renal proximal and distal tubules of Wistar rats and the intensity of nephrotoxicity correlated with the dose of oral administration.
氯菊酯（CYP）是一种重要的 II 型拟除虫菊酯农药，广泛用于保护作物免受虫害和昆虫侵害。然而，其毒性对人类健康和周围环境构成风险。本研究旨在探讨氯菊酯对成年 Wistar 大鼠肾脏组织的肾毒性作用和组织病理学变化。在这项研究中，将 30 只 Wistar 大鼠等分为三组。G1 为对照组；G2 和 G3 分别用不同的亚致死剂量 CYP 处理 30 天：G2 为低剂量（LD50 的 1/100）；G3 为高剂量（LD50 的 1/50）。用透射电子显微镜观察肾近端和远端细胞不同细胞器的损伤。用形态学和组织学测量法确认肾组织样本的组织病理学损伤。结果表明，CYP 对处理大鼠的肾近端和远端小管造成了显著的组织病理学损伤。与对照组相比，CYP 导致处理细胞的细胞核、卵形和丝状线粒体的尺寸发生了明显改变。总之，氯菊酯对哺乳动物具有毒性。它对 Wistar 大鼠的肾近端和远端小管造成了明显的超微结构损伤，且肾毒性的强度与口服剂量相关。
