Clinical Pharmacy Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Clinical & Hospital Pharmacy Department, College of Pharmacy, Taibah University, Medina, Saudi Arabia.
J Comp Eff Res. 2020 Sep;9(13):907-918. doi: 10.2217/cer-2020-0076. Epub 2020 Sep 24.
Venous leg ulcers (VLUs) present a significant economic burden on the US healthcare system and payers (US$14.9 billion). To evaluate the quality of life (QoL) of patients with VLUs; to analyze the limitations of standard of care (SOC) for VLUs; and to explain how using bilayered living cellular construct (BLCC) with SOC for treatment of VLUs can help heal more VLUs faster (than using SOC alone) as well as help improve QoL and help reduce the burden on the US healthcare system and payers. This is a review study. The search was conducted in February 2020 by way of electronic databases to find relevant articles that provided information related to QoL of patients with VLUs, limitations of SOC for VLUs and economic analyses of using BLCC for treatment of VLUs. VLUs impact patients' physical, functional and psychological status and reduce QoL. A total 75% of VLU patients who used SOC alone failed to achieve healing in a timely fashion, which led to increased healthcare costs and healthcare resource utilization. Although the upfront cost is high, the greater effectiveness of BLCC offsets the added cost of the product during the time period of the studies. Therefore, BLCC helps to improve the QoL of VLU patients. As an example, for every 100 VLU patients in a healthcare plan, the use of BLCC can create cost savings of US$1,349,829.51. Payers' coverage of BLCC results in reduction of the overall medical cost for treating VLU patients.
静脉性腿部溃疡（VLUs）给美国医疗保健系统和支付方带来了巨大的经济负担（149 亿美元）。评估 VLUs 患者的生活质量（QoL）；分析 VLUs 标准治疗（SOC）的局限性；并解释使用双层活细胞构建体（BLCC）联合 SOC 治疗 VLUs 如何帮助更快地治愈更多的 VLUs（比单独使用 SOC 更快），以及如何帮助提高 QoL 并帮助减轻美国医疗保健系统和支付方的负担。这是一项综述研究。2020 年 2 月，通过电子数据库进行了检索，以寻找提供有关 VLUs 患者 QoL、SOC 对 VLUs 的局限性以及使用 BLCC 治疗 VLUs 的经济分析相关信息的相关文章。VLUs 会影响患者的身体、功能和心理状态，降低 QoL。有 75%的单独使用 SOC 的 VLU 患者未能及时治愈，这导致医疗保健成本和医疗资源利用增加。尽管前期成本较高，但 BLCC 的更高疗效抵消了研究期间产品附加成本。因此，BLCC 有助于提高 VLU 患者的 QoL。例如，在医疗保健计划中每有 100 名 VLU 患者，使用 BLCC 可节省 1349829.51 美元的成本。支付方对 BLCC 的覆盖范围降低了治疗 VLU 患者的总体医疗成本。
