Nephrology and Kidney Transplantation Unit, Department of Translational Medicine, University of Piemonte Orientale, "Maggiore della Carità" University Hospital, Novara, Italy.
Icahn School of Medicine at Mount Sinai, New York, New York.
Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F792-F795. doi: 10.1152/ajprenal.00245.2020. Epub 2020 Sep 24.
Coronavirus disease 2019 (COVID-19) poses an unprecedented challenge to world health systems, substantially increasing hospitalization and mortality rates in all affected countries. Being primarily a respiratory disease, COVID-19 is mainly associated with pneumonia or minor upper respiratory tract symptoms; however, different organs can sustain considerable (if not terminal) damage because of coronavirus. Acute kidney injury is the most common complication of COVID-19-related pneumonia, and more than 20% of patients requiring ventilatory support develop renal failure. Additionally, chronic kidney disease is a major risk factor for COVID-19 severity and mortality. All these data demonstrate the relevance of renal function assessment in patients with COVID-19 and the need of early kidney-directed diagnostic and therapeutic approaches. However, the sole assessment of renal function could be not entirely indicative of kidney tissue status. In this viewpoint, we discuss the clinical significance and potential relevance of renal functional reserve evaluation in patients with COVID-19.
新型冠状病毒病 2019（COVID-19）对世界卫生系统构成了前所未有的挑战，使所有受影响国家的住院率和死亡率大幅上升。COVID-19 主要是一种呼吸道疾病，主要与肺炎或轻微的上呼吸道症状有关；然而，由于冠状病毒，不同的器官可能会受到相当大的（如果不是致命的）损害。急性肾损伤是 COVID-19 相关肺炎最常见的并发症，超过 20%需要通气支持的患者发生肾衰竭。此外，慢性肾脏病是 COVID-19 严重程度和死亡率的主要危险因素。所有这些数据都表明了在 COVID-19 患者中评估肾功能的重要性，以及早期针对肾脏的诊断和治疗方法的必要性。然而，仅评估肾功能可能不完全表明肾脏组织的状态。在这篇观点文章中，我们讨论了在 COVID-19 患者中评估肾功能储备的临床意义和潜在相关性。
