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肾移植受者 COVID-19 肺炎成功接受托珠单抗和羟氯喹治疗。

COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine.

机构信息

Struttura Complessa di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.

Surgical Medical and Dental Department of Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.

出版信息

Am J Transplant. 2020 Jul;20(7):1902-1906. doi: 10.1111/ajt.15935. Epub 2020 May 13.

Abstract

Coronavirus disease 2019 (COVID-19) pneumonia has been poorly reported in solid organ transplanted patients; prognosis is uncertain and best management unclear. We describe the case of a 61-year-old kidney transplant recipient with several comorbidities who was hospitalized and later received a diagnosis of COVID-19 pneumonia; the infection was successfully managed with the use of hydroxychloroquine and a single administration of tocilizumab, after immunosuppression reduction; the patient did not require mechanical ventilation. During the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, transplant clinicians should be readily informed about new cases of COVID-19 pneumonia in solid organ transplant recipients, with focus on therapeutic strategies employed and their outcome.

摘要

2019 冠状病毒病(COVID-19)肺炎在实体器官移植患者中报道较少;预后不确定,最佳治疗方法尚不清楚。我们描述了一例 61 岁的肾移植受者,合并多种合并症,住院后被诊断为 COVID-19 肺炎;通过减少免疫抑制,使用羟氯喹和单次托珠单抗治疗,成功控制了感染;患者无需机械通气。在严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)大流行迅速传播期间,移植临床医生应随时了解实体器官移植受者中新发的 COVID-19 肺炎病例,重点关注所采用的治疗策略及其结果。

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本文引用的文献

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Clinical Characteristics of Coronavirus Disease 2019 in China.《中国 2019 年冠状病毒病临床特征》
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