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首发精神分裂症患者的自杀思维和行为:“帕尔马早期精神病”项目 24 个月随访研究结果。

Suicidal Thinking and Behavior in First Episode Schizophrenia: Findings from the 24-Month Follow-Up of the "Parma Early Psychosis" Program.

出版信息

Arch Suicide Res. 2022 Apr-Jun;26(2):656-676. doi: 10.1080/13811118.2020.1820411. Epub 2020 Sep 24.

Abstract

Although suicide risk is relevant in First Episode Schizophrenia (FES), little data are reported on suicidal ideation and its longitudinal stability. Aim of this study was: (1) to evaluate incidence rates of suicide attempts, completed suicide and suicidal thinking in FES patients at baseline and along a 24-month follow-up period, (2) to investigate any relevant association of baseline suicidal ideation with psychopathology, and (3) to longitudinally monitor suicidal thinking during the 2-years of follow-up. Participants ( = 149; age = 12-35 years) were assessed with the Brief Psychiatric Rating Scale (BPRS) and the Positive and Negative Syndrome Scale. FES participants showed a 40.8% percentage of baseline suicidal ideation (i.e., BPRS item 4 cutoff score of ≥3) and a 2-year cumulative incidence rate of attempted suicide of 6.1%. One completed suicide (0.7%) was also found during the follow-up. Baseline suicidal ideation was positively correlated with depression and negatively correlated with younger age. These results support a routine monitoring of suicide risk in this young population at the point of entry into early intervention services.

摘要

尽管自杀风险在首发精神分裂症(FES)中很重要,但关于自杀意念及其纵向稳定性的报道很少。本研究的目的是:(1)评估 FES 患者在基线和 24 个月随访期间自杀企图、自杀死亡和自杀意念的发生率;(2)探讨基线自杀意念与精神病理学的任何相关关联;(3)在 2 年随访期间纵向监测自杀意念。参与者( = 149;年龄为 12-35 岁)接受了简明精神病评定量表(BPRS)和阳性和阴性综合征量表的评估。FES 参与者的基线自杀意念率为 40.8%(即 BPRS 项目 4 的截止得分≥3),2 年累积自杀企图率为 6.1%。在随访期间还发现了 1 例自杀死亡(0.7%)。基线自杀意念与抑郁呈正相关,与年龄较小呈负相关。这些结果支持在早期干预服务的初始阶段,对这一年轻人群的自杀风险进行常规监测。

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