挽救性伽玛刀立体定向放射外科治疗复发性颅内朗格汉斯细胞组织细胞增生症：36 年的传奇历程。
Salvage Gamma Knife Stereotactic Radiosurgery for Recurrent Intracranial Langerhans Cell Histiocytosis: A 36-Year Saga.
机构信息
Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
出版信息
World Neurosurg. 2020 Dec;144:205-208. doi: 10.1016/j.wneu.2020.09.090. Epub 2020 Sep 22.
BACKGROUND
Management of intracranial Langerhans cell histiocytosis generally includes surgical resection.
CASE DESCRIPTION
A female patient with a diagnosis of Langerhans cell histiocytosis developed multiple brain lesions. As part of her multimodality treatment, she underwent Gamma Knife stereotactic radiosurgery on 4 occasions over a 20-year period. All tumors showed significant shrinkage on serial imaging after initially demonstrating a transient expansion. No permanent postradiosurgery complications occurred.
CONCLUSIONS
As part of multimodality management of this recurrent and refractory disease, Gamma Knife stereotactic radiosurgery should be considered an important salvage option that can control local disease and obviate the need for invasive surgery.
背景
颅内朗格汉斯细胞组织细胞增生症的治疗一般包括手术切除。
病例描述
一名女性朗格汉斯细胞组织细胞增生症患者出现多处脑部病变。作为多模式治疗的一部分，她在 20 年内接受了 4 次伽玛刀立体定向放射外科手术。所有肿瘤在最初短暂扩张后连续影像学检查均显示显著缩小。无永久性放射外科手术后并发症发生。
结论
作为这种复发性和难治性疾病的多模式治疗的一部分，伽玛刀立体定向放射外科手术应被视为一种重要的挽救性选择，可以控制局部疾病，避免需要进行侵入性手术。
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